2140-72-9Relevant articles and documents
Efficient large scale synthesis of 2′-O-alkyl pyrimidine ribonucleosides
Roy, Saroj K.,Tang, Jin-Yan
, p. 170 - 171 (2000)
An efficient process to synthesize 2′-O-alkyl pyrimidine ribonucleosides in high yield has been described. The inexpensive method was used on a multikilogram-scale synthesis and optimized reaction conditions have been investigated.
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Hingerty et al.
, p. 1349 (1977)
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Hudson et al.
, p. 2009 (1965)
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Synthesis and solution conformation studies of the modified nucleoside N4,2′-O-dimethylcytidine (m4Cm) and its analogues
Mahto, Santosh K.,Chow, Christine S.
, p. 8795 - 8800 (2008/12/23)
The dimethylated ribosomal nucleoside m4Cm and its monomethylated analogues Cm and m4C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modification (e.g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine.
2'modified oligonucleotides
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, (2008/06/13)
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.