21397-07-9

Basic information

• Product Name: 2-Chloro-3-fluoronitrobenzene
• Synonyms: 1-CHLORO-2-FLUORO-6-NITRO-BENZENE;2-CHLORO-3-FLUORONITROBENZENE;2-CHLORO-1-FLUORO-3-NITRO-BENZENE;1-Nitro-2-chloro-3-fluorobenzene;Benzene, 2-chloro-1-fluoro-3-nitro-
• CAS NO: 21397-07-9
• Molecular Formula: C₆H₃ClFNO₂
• Molecular Weight: 175.54
• EINECS: 244-365-6
• Product Categories: Multisubstituted Benzene;Aromatic Halides (substituted);Benzenes
• Mol File: 21397-07-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 243.3°C at 760 mmHg
• Flash Point: 101 °C
• Appearance: /
• Density: 1.494 g/cm³
• Vapor Pressure: 0.0503mmHg at 25°C
• Refractive Index: 1.554
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Chloro-3-fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-fluoronitrobenzene(21397-07-9)
• EPA Substance Registry System: 2-Chloro-3-fluoronitrobenzene(21397-07-9)

Safety Data

• Hazard Codes: T
• Hazardous Substances Data: 21397-07-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-3-fluoronitrobenzene is utilized as a building block in organic synthesis for the production of pharmaceuticals. Its unique structure allows for the creation of various medicinal compounds, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-3-fluoronitrobenzene serves as a key intermediate in the synthesis of various agrochemicals, aiding in the development of effective pesticides and other agricultural products.
Used in Dye and Pigment Industry:
2-Chloro-3-fluoronitrobenzene is also employed in the manufacturing of dyes and pigments, where its chemical properties enable the production of a wide range of colorants for different applications.
Used in Chemical Intermediates:
2-Chloro-3-fluoronitrobenzene is a valuable chemical intermediate for various industrial applications, facilitating the synthesis of diverse chemical products and contributing to the advancement of the chemical industry.

InChI:InChI=1/C6H3ClFNO2/c7-6-4(8)2-1-3-5(6)9(10)11/h1-3H

Upstream product

• 602-03-9 2,3-dinitroaniline 
• 611-06-3 2,4-dichloronitrobenzene 
• 402-67-5 3-fluoro-1-nitrobenzene 
• 342-52-9 N-(2-fluoro-6-nitrophenyl)acetamide 
• 399-31-5 N-(2-fluorophenyl)acetamide 
• 17809-36-8 2-fluoro-6-nitroaniline 

Downstream Products

• 17809-36-8 2-fluoro-6-nitroaniline 
• 169673-92-1 7-chloro-6-fluoroindole 
• 1247021-61-9 [(2-fluoro-6-nitrophenyl)sulfanyl]acetic acid 
• 1234010-04-8 C₁₀H₁₂FN₃O₂ 
• 21397-08-0 2-chloro-3-fluoroaniline 

Relevant articles and documents

Preparation method of 2 - fluorine -6 - nitroaniline

The invention discloses a preparation method of 2 -fluoro -6 - nitroaniline, and the specific steps of the preparation method are as follows: (1) taking M-fluoronitrobenzene as a starting raw material, reacting with hexachloroethane under the catalysis condition of tert-butyl alcohol lithium III, and reacting with hexachloroethane. (2) Compound III amine is hydrolyzed to give compound I. That is, the 2 - fluorine -6 - nitroaniline. To the invention, a large amount of easily toxic and easily-produced reagents are avoided in the full synthetic route process taking the meta-fluoronitrobenzene as a starting raw material, and the raw materials are low in price.

Design, synthesis and herbicidal activity study of aryl 2,6-disubstituted sulfonylureas as potent acetohydroxyacid synthase inhibitors

A series of sulfonylurea derivatives containing a 2,6-disubstituted aryl moiety were designed, synthesized and evaluated for their herbicidal activities. Most of these compounds showed excellent inhibitory rates against both monocotyledonous and dicotyledonous weeds, especially 10a, 10h and 10i. They exhibited equivalent or superior herbicidal efficiency than commercial chlorsulfuron at the dosage of 15?g/ha and the preliminary SAR was summarized. In order to illuminate the molecular mechanism of several potent compounds, their apparent inhibition constant (Kiapp) of Arabidopsis thaliana acetohydroxyacid synthase (AHAS) were determined and the results confirmed that these compounds were all potent AHAS inhibitors. 10i have a Kiapp of 11.5?nM, which is about 4 times as potent as chlorsulfuron (52.4?nM).

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists

Novell IL-8 compounds and methods of using them are provided.

Process for the synthesis of fluorinated derivatives

A process for the synthesis of fluorinated organic compounds and a reagent suitable for use in the process. The process is carried out by exchange with fluorides, while preferably agitating the reaction medium with ultrasonic sound.