2136-75-6Relevant articles and documents
Synthesis of 9- and 12-nitro conjugated linoleic acid: Regiospecific isomers of naturally occurring conjugated nitrodienes
Woodcock, Steven R.,Salvatore, Sonia R.,Freeman, Bruce A.,Schopfer, Francisco J.
supporting information, (2021/09/13)
Conjugated diene-containing fatty acids (rumenic and rumelenic acids) are major substrates for nitration under physiological conditions. Their nitrated products are present in human urine. These nitrodiene-containing lipid electrophiles contain a strongly electron-withdrawing pair of conjugated double bonds amenable to nucleophilic attack in biological milieu, which affords them pluripotent signaling capabilities. We report synthetic methods to obtain useful quantities of three main biological nitrated fatty acids (9- and 12-nitro-conjugated linoleic acids and 9-nitro-conjugated linolenic acid) in six or seven steps from commercially available starting materials, for biological evaluation of these naturally occurring biomolecules.
Method for preparing formyl methylene triphenylphosphine
-
Paragraph 0008; 0019-0020; 0024-0026; 0030, (2020/12/14)
The invention discloses a method for preparing formyl methylene triphenylphosphine. The method comprises the following steps: reacting triphenylphosphine with excessive chloroacetaldehyde dimethyl acetal under the catalysis of a proper catalyst to obtain corresponding quaternary phosphonium salt; dissolving quaternary phosphonium salt in water, adding a trace amount of inorganic acid to hydrolyzethe quaternary phosphonium salt, dropwise adding the hydrolyzed quaternary phosphonium salt into an aqueous solution of alkali according to a conventional method, and filtering and washing precipitates to directly obtain formyl methylene triphenylphosphine. The method has the advantages of no use of expensive reagents, simple operation, high yield, less three wastes, and easy realization of industrialization.
Preparation method of (formylmethylene) triphenyl orthophosphonium
-
Paragraph 0019; 0029; 0046-0050, (2018/03/25)
The invention discloses a preparation method of (formylmethylene) triphenyl orthophosphonium, and relates to the technical field of chemical substance preparation. The preparation method specificallycomprises the following steps of: carrying out a hydrolysis reaction on 2-bromo-1,1-dimethoxyethane under an acidic condition to obtain 1-bromoacetaldehyde; reacting 1-bromoacetaldehyde with triphenylphosphine to obtain a transition state intermediate quaternary phosphine salt namely 2-aldehyde ethyl triphenylphosphine bromide; and adding alkali into an aprotic solvent to obtain a product namely (formylmethylene) triphenyl orthophosphonium by losing one molecule of hydrogen bromide. The preparation method provided by the invention has the advantages of short synthesis route, easy synthesis, simple operation, cheap and easily obtained raw materials, less side reactions, high yield and high purity of the prepared (formylmethylene) triphenyl orthophosphonium, and is suitable for industrial production.