213318-44-6 Usage
Description
N-Boc-indole-2-boronic acid is a white to light yellow crystalline powder that serves as a versatile reagent in organic synthesis. It is characterized by its chemical properties, which include the presence of an indole ring and a boronic acid group, as well as a Boc-protecting group on the nitrogen atom. N-Boc-indole-2-boronic acid may contain varying amounts of anhydride.
Uses
Used in Pharmaceutical Industry:
N-Boc-indole-2-boronic acid is used as a synthetic intermediate for the preparation of various pharmaceutical compounds. Its reactivity in cross-coupling reactions allows for the efficient construction of complex organic molecules, which are often found in drug candidates.
Used in Chemical Research:
In the field of chemical research, N-Boc-indole-2-boronic acid is utilized as a reactant in various organic reactions, such as Suzuki-Miyaura cross-coupling reactions, copper-catalyzed trifluoromethylation, palladium-catalyzed benzylation, and homocoupling reactions. These reactions enable the synthesis of a wide range of organic compounds with potential applications in materials science, agrochemicals, and other industries.
Used in Material Science:
N-Boc-indole-2-boronic acid is employed as a building block in the development of new materials with unique properties. Its ability to participate in cross-coupling reactions allows for the creation of novel polymers, dendrimers, and other advanced materials with potential applications in electronics, sensors, and other high-tech fields.
Overall, N-Boc-indole-2-boronic acid is a valuable chemical entity with diverse applications across various industries, including pharmaceuticals, chemical research, and material science. Its unique reactivity and functional groups make it an essential component in the synthesis of complex organic molecules and the development of innovative materials.
Check Digit Verification of cas no
The CAS Registry Mumber 213318-44-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,3,1 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 213318-44:
(8*2)+(7*1)+(6*3)+(5*3)+(4*1)+(3*8)+(2*4)+(1*4)=96
96 % 10 = 6
So 213318-44-6 is a valid CAS Registry Number.
InChI:InChI=1/C13H16BNO4/c1-13(2,3)19-12(16)15-10-7-5-4-6-9(10)8-11(15)14(17)18/h4-8,17-18H,1-3H3
213318-44-6Relevant articles and documents
NEW COMPOUND HAVING FGFR INHIBITORY ACTIVITY AND PREPARATION AND APPLICATION THEREOF
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, (2019/05/30)
The present invention relates to a new compound having an FGFR inhibitory activity and preparation and application thereof. In particular, the compound according to the present invention has a structure as shown in formula I, wherein each group and substituent are as defined in the description. Also disclosed in the present invention are a preparation method for the compound and a use thereof in preparation of a drug for treating and/or preventing a tumor-related disease and/or an FGFR-related disease.
Potassium [1-(tert-butoxycarbonyl)-1H-indol-2-yl]trifluoroborate as an efficient building block in palladium-catalyzed Suzuki-Miyaura cross couplings
Kassis, Pamela,Beneteau, Valerie,Merour, Jean-Yves,Routier, Sylvain
experimental part, p. 2447 - 2453 (2010/02/27)
Potassium [1-(tert-butoxycarbonyl)-1H-indol-2-yl]trifluoroborate (1) was used in Suzuki-type coupling reactions. First, the best coupling conditions were assessed using bromobenzene as the electrophile. Then, 1 was successfully coupled with various aryl a
Combined directed ortho and remote metalation-suzuki cross-coupling strategies. Efficient synthesis of heteroaryl-fused benzopyranones from biaryl O-carbamates
James, Clint A.,Coelho, Antonio Luiz,Gevaert, Matt,Forgione, Pat,Snieckus, Victor
experimental part, p. 4094 - 4103 (2009/09/25)
(Chemical Equation Presented) A concise synthesis of heteroaryl dibenzopyranones 9a,b, 10a,b, 11a-c, and 12a-c has been achieved by the LDA-induced migration of heterobiaryl O-carbamates 18, 21, 25, and 30 which, in turn, were prepared in good yield using
