21331-43-1Relevant articles and documents
Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies
Sroor, Farid M.,Othman, Abdelmageed M.,Aboelenin, Mohamad M.,Mahrous, Karima F.
, p. 400 - 415 (2022/01/31)
The drug resistance became the major challenge in the antimicrobial and anticancer drugs therapy. Therefore, there is an urgent need to looking for new types of antimicrobial and anticancer agents. Herein we reported the synthesis and biological evaluatio
Synthesis of new thiazole derivatives and evaluation of their antimicrobial and cytotoxic activities
Dawbaa, Sam,Evren, Asaf Evrim,Cantürk, Zerrin,Yurtta?, Leyla
, p. 1093 - 1102 (2021/09/13)
Novel 2-heteroaryl-N-[4-(substituted aryl)thiazol-2-yl]propanamide derivatives (7a–7o) were synthesized and investigated for their antimicrobial activity. Among the tested compounds, 2-[(1H-Benzimidazol-2-yl)thio]-N-[4-(naphthalen-2-yl)thiazol-2-yl]propan
SUBSTITUTED PROPANAMIDES AS INHIBITORS OF NUCLEASES
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Page/Page column 11; 13; 23; 24; 29, (2019/11/12)
The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3, R4, R5, R6 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.