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213192-26-8

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213192-26-8 Usage

Chemical compound

2-AMINO-6-TERT-BUTYL-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER

Structure

Methyl ester of the carboxylic acid derivative of 2-amino-6-tert-butyl-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid

Uses

Commonly used in pharmaceutical research for its potential therapeutic properties

Heterocyclic structure

Consists of a benzothiophene ring with an amino group and a tert-butyl group

Synthesis

Used in the synthesis of various bioactive compounds

Potential properties

Studies have shown potential as an anti-inflammatory and analgesic agent

Ongoing research

Further research on its pharmacological properties is ongoing

Check Digit Verification of cas no

The CAS Registry Mumber 213192-26-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,1,3,1,9 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 213192-26:
(8*2)+(7*1)+(6*3)+(5*1)+(4*9)+(3*2)+(2*2)+(1*6)=98
98 % 10 = 8
So 213192-26-8 is a valid CAS Registry Number.

213192-26-8Relevant articles and documents

Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel

De La Fuente, Ricardo,Namkung, Wan,Mills, Aaron,Verkman, Alan S.

, p. 758 - 768 (2008)

Calcium-activated chloride channels (CaCCs) are widely expressed in mammalian tissues, including intestinal epithelia, where they facilitate fluid secretion. Potent, selective CaCC inhibitors have not been available. We established a high-throughput scree

Syntheses and biological evaluation of 2-amino-3-acyl- tetrahydrobenzothiophene derivatives; Antibacterial agents with antivirulence activity

The Dang, Hung,Chorell, Erik,Uvell, Hanna,Pinkner, Jerome S.,Hultgren, Scott J.,Almqvist, Fredrik

, p. 1942 - 1956 (2014/03/21)

Developing new compounds targeting virulence factors (e.g., inhibition of pilus assembly by pilicides) is a promising approach to combating bacterial infection. A high-throughput screening campaign of a library of 17500 small molecules identified 2-amino-3-acyl-tetrahydrobenzothiophene derivatives (hits 2 and 3) as novel inhibitors of pili-dependent biofilm formation in a uropathogenic Escherichia coli strain UTI89. Based on compounds 2 and 3 as the starting point, we designed and synthesized a series of structurally related analogs and investigated their activity against biofilm formation of E. coli UTI89. Systematic structural modification of the initial hits provided valuable information on their SARs for further optimization. In addition, small structural changes to the parent molecules resulted in low micromolar inhibitors (20-23) of E. coli biofilm development without an effect on bacterial growth. The hit compound 3 and its analog 20 were confirmed to prevent pili formation in a hemagglutination (HA) titer assay and electron microscopy (EM) measurements. These findings suggest that 2-amino-3-acyl-tetrahydrobenzothiophenes may serve as a new class of compounds for further elaboration as antibacterial agents with antivirulence activity.

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