212779-21-0

Basic information

• Product Name: 2-Amino-3-bromo-6-chloropyrazine
• Synonyms: 2-Amino-3-bromo-6-chloropyrazine;2-PyrazinaMine, 3-broMo-6-chloro-;3-Bromo-6-chloro-2-pyrazinamine;3-Bromo-6-chloro-pyrazin-2-ylamine
• CAS NO: 212779-21-0
• Molecular Formula: C4H3BrClN3
• Molecular Weight: 208.446
• Mol File: 212779-21-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 299.5 °C at 760 mmHg
• Flash Point: 134.9 °C
• Appearance: /
• Density: 1.960
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.05±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-bromo-6-chloropyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-6-chloropyrazine(212779-21-0)
• EPA Substance Registry System: 2-Amino-3-bromo-6-chloropyrazine(212779-21-0)

Safety Data

• Hazardous Substances Data: 212779-21-0(Hazardous Substances Data)

Usage

Description

2-Amino-3-bromo-6-chloropyrazine is a chemical compound that falls under the class of pyrazines, which are organic compounds characterized by a pyrazine ring—a six-membered aromatic ring with two nitrogen atoms. 2-Amino-3-bromo-6-chloropyrazine is distinguished by the presence of an amino group, a bromine atom, and a chlorine atom in its structure. While specific details about its physical and chemical properties such as boiling point, density, molecular weight, and solubility may not be readily available, its potential applications in various industries like pharmaceutical and chemical manufacturing could be significant. As with other chemicals, it is important to consider appropriate safety measures when handling 2-Amino-3-bromo-6-chloropyrazine to mitigate potential health risks or hazards.

Uses

Used in Pharmaceutical Industry:
2-Amino-3-bromo-6-chloropyrazine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with a pyrazine ring and halogenated substituents makes it a valuable building block in the development of new drugs, potentially contributing to the creation of novel therapeutic agents.
Used in Chemical Manufacturing:
2-Amino-3-bromo-6-chloropyrazine is used as a reagent or catalyst in certain chemical reactions, facilitating the production of other compounds. Its presence in the reaction mixture can influence the outcome, making it a useful tool in the synthesis of complex organic molecules.
Used in Research and Development:
2-Amino-3-bromo-6-chloropyrazine is used as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to understand its potential applications and to explore new methods for its synthesis and modification, which could lead to the discovery of new materials or processes.

InChI:InChI=1/C4H3BrClN3/c5-3-4(7)9-2(6)1-8-3/h1H,(H2,7,9)

Upstream product

• 33332-28-4 2-amino-6-chloropyrazine 
• 128-08-5 N-Bromosuccinimide 

Downstream Products

• 1801693-41-3 tert-butyl N-(3-bromo-6-chloropyrazin-2-yl)-N-[(tert-butoxy)carbonyl]carbamate 

Relevant articles and documents

Synthesis process of 2-amino-3-bromo-6-chloropyrazine

The invention relates to a synthesis process of 2-amino-3-bromo-6-chloropyrazine, which comprises the following steps: 1) adding 2-amino-6-chloropyrazine into an organic solvent, cooling the system, and then adding a catalyst; (2) dropwise adding a bromination reagent, namely liquid bromine, into the system, after dropwise adding is finished, carrying out heat preservation reaction, and carrying out TLC detection and tracking reaction; and 3) adding a sodium sulfite solution into the system until reddish brown fades, extracting with chloroform, washing with water, drying with anhydrous sodium sulfate, concentrating, passing through a silicagel column roughly, and recrystallizing to obtain the yellow solid compound 2-amino-3-bromine- 6-chloropyrazine. 2-amino-3-bromine- 6-chloropyrazine is used as an initial raw material and is brominated to obtain the product, so that the method is simple to operate, short in step, easily available in raw material, simple to purify, high in yield, low in cost and easy for large-scale production.

PROCESS OF MANUFACTURE OF A COMPOUND FOR INHIBITING THE ACTIVITY OF SHP2

The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II wit

COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.