212779-21-0

Basic information

• Product Name: 2-Amino-3-bromo-6-chloropyrazine
• Synonyms: 2-Amino-3-bromo-6-chloropyrazine;2-PyrazinaMine, 3-broMo-6-chloro-;3-Bromo-6-chloro-2-pyrazinamine;3-Bromo-6-chloro-pyrazin-2-ylamine
• CAS NO: 212779-21-0
• Molecular Formula: C4H3BrClN3
• Molecular Weight: 208.446
• Mol File: 212779-21-0.mol

Chemical Properties

• Boiling Point: 299.5 °C at 760 mmHg
• Flash Point: 134.9 °C
• Appearance: /
• Density: 1.960
• Vapor Pressure: 0.00119mmHg at 25°C
• Refractive Index: 1.66
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.05±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-3-bromo-6-chloropyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-bromo-6-chloropyrazine(212779-21-0)
• EPA Substance Registry System: 2-Amino-3-bromo-6-chloropyrazine(212779-21-0)

Safety Data

• Hazardous Substances Data: 212779-21-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-3-bromo-6-chloropyrazine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure with a pyrazine ring and halogenated substituents makes it a valuable building block in the development of new drugs, potentially contributing to the creation of novel therapeutic agents.
Used in Chemical Manufacturing:
2-Amino-3-bromo-6-chloropyrazine is used as a reagent or catalyst in certain chemical reactions, facilitating the production of other compounds. Its presence in the reaction mixture can influence the outcome, making it a useful tool in the synthesis of complex organic molecules.
Used in Research and Development:
2-Amino-3-bromo-6-chloropyrazine is used as a research compound in academic and industrial laboratories. Its properties and reactivity are studied to understand its potential applications and to explore new methods for its synthesis and modification, which could lead to the discovery of new materials or processes.

InChI:InChI=1/C4H3BrClN3/c5-3-4(7)9-2(6)1-8-3/h1H,(H2,7,9)

Upstream product

• 33332-28-4 2-amino-6-chloropyrazine 
• 128-08-5 N-Bromosuccinimide 

Downstream Products

• 1801693-41-3 tert-butyl N-(3-bromo-6-chloropyrazin-2-yl)-N-[(tert-butoxy)carbonyl]carbamate 

Relevant articles and documents

Synthesis process of 2-amino-3-bromo-6-chloropyrazine

The invention relates to a synthesis process of 2-amino-3-bromo-6-chloropyrazine, which comprises the following steps: 1) adding 2-amino-6-chloropyrazine into an organic solvent, cooling the system, and then adding a catalyst; (2) dropwise adding a bromination reagent, namely liquid bromine, into the system, after dropwise adding is finished, carrying out heat preservation reaction, and carrying out TLC detection and tracking reaction; and 3) adding a sodium sulfite solution into the system until reddish brown fades, extracting with chloroform, washing with water, drying with anhydrous sodium sulfate, concentrating, passing through a silicagel column roughly, and recrystallizing to obtain the yellow solid compound 2-amino-3-bromine- 6-chloropyrazine. 2-amino-3-bromine- 6-chloropyrazine is used as an initial raw material and is brominated to obtain the product, so that the method is simple to operate, short in step, easily available in raw material, simple to purify, high in yield, low in cost and easy for large-scale production.

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

PROCESS OF MANUFACTURE OF A COMPOUND FOR INHIBITING THE ACTIVITY OF SHP2

The invention relates to a method for the manufacture of a compound of Formula I as mentioned above, or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II wit

Large-scale process for preparing 2-amino-3-bromo-6-chloropyrazine

The invention discloses a large-scale process for preparing 2-amino-3-bromo-6-chloropyrazine. The product is obtained from 3-aminopyrazine-2-carboxylate as a raw material through steps of chlorination, diazotization bromination, ester group hydrolysis, carboxyl rearrangement, t-butyloxycarbonyl removal and the like. The process is higher in yield, simple in purification, prone to large-scale production and capable of realizing effective and low-cost production.

COMPOUNDS FOR USE IN ANTIBACTERIAL APPLICATIONS

The present invention relates to novel compounds or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions and treatment methods or uses as antibacterials for bacterial infections.

SUBSTITUTED TETRAHYDROQUINOLINONE COMPOUNDS AS ROR GAMMA MODULATORS

The present invention provides substituted tetrahydroquinolinone and related compounds of formula (I), which are therapeutically useful as modulators of Retinoic acid receptor-related orphan receptors (RORs), more particularly as RORγ modulators. These co

TRICYCLIC DLK INHIBITORS AND USES THEREOF

The invention relates to compounds of formula (I) and salts thereof, wherein ring A and R1-R2 have any of the values defined in the specification. The compounds and salts are useful for treating DLK mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as methods of using said compounds, salts, or compositions as DLK inhibitors and for treating neurodegeneration diseases and disorders.

ANTICANCER PYRIDOPYRAZINES VIA THE INHIBITION OF FGFR KINASES

The invention relates to new pyridopyrazine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

INHIBITORS OF JAK

The present invention relates to the use of novel compounds of Formula I, wherein the variables m, n, p, q, Q, r, R, R′, X, X′, Y, Z1, Z2, and Z3 are defined as described herein, which inhibit JAK and are useful for the treatment of auto-immune and inflammatory diseases.

BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.