2110-16-9

Basic information

• Product Name: 2-(1-phenethyl-3-phenyl-propyl)-pyridine
• Synonyms: 2-(1-phenethyl-3-phenyl-propyl)-pyridine
• CAS NO: 2110-16-9
• Molecular Weight: 301.431
• Mol File: 2110-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(1-phenethyl-3-phenyl-propyl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-phenethyl-3-phenyl-propyl)-pyridine(2110-16-9)
• EPA Substance Registry System: 2-(1-phenethyl-3-phenyl-propyl)-pyridine(2110-16-9)

Safety Data

• Hazardous Substances Data: 2110-16-9(Hazardous Substances Data)

Upstream product

• 109-06-8 α-picoline 
• 100-42-5 styrene 
• 622-24-2 2-phenylethyl chloride 

Relevant articles and documents

Potassium Amide-Catalyzed Benzylic C?H Bond Addition of Alkylpyridines to Styrenes

The benzylic functionalization of alkylpyridines is an important pathway for pyridine derivatives synthesis. The reaction partners, however, were mostly limited to highly reactive polar electrophiles. Herein, we report a potassium amide-catalyzed selective benzylic C?H bond addition of alkylpyridines to styrenes. Potassium bis(trimethylsilyl)amide (KHMDS), a readily available Br?nsted base, showed excellent catalytic activity and chemoselectivity. A series of alkylpyridine derivatives, including benzylic quaternary carbon substituted pyridines, were obtained in good to high yield. Preliminary mechanistic studies revealed that the deprotonation equilibrium is probably responsible for the excellent selectivity.