20970-75-6

Basic information

• Product Name: 3-Methylpicolinonitrile
• Synonyms: 3-Methylpicolinonitr;2-Cyano-3-picoline 3-Methylpicolinonitrile;Cyano-3-methylpyridine;2-CYANO-3-METHYLPYRIDINE;2-CYANO-3-PICOLINE;3-METHYLPICOLINONITRILE;3-METHYL-PYRIDINE-2-CARBONITRILE;3-METHYL-2-PYRIDINECARBONITRILE
• CAS NO: 20970-75-6
• Molecular Formula: C₇H₆N₂
• Molecular Weight: 118.14
• EINECS: 244-131-3
• Product Categories: FINE Chemical & INTERMEDIATES;blocks;Carboxes;Pyridines;Pyridines, Pyrimidines, Purines and Pteredines;Pyridine;Pyridines derivates;Heterocyclic Compounds;C7 and C8;Heterocyclic Building Blocks
• Mol File: 20970-75-6.mol
• Article Data: 20

Chemical Properties

• Melting Point: 83-87 °C(lit.)
• Boiling Point: 141°C 38mm
• Flash Point: 115°C
• Appearance: Light beige/Crystalline Powder
• Density: 1.1151 (rough estimate)
• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: -0.03±0.10(Predicted)
• BRN: 112001
• CAS DataBase Reference: 3-Methylpicolinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methylpicolinonitrile(20970-75-6)
• EPA Substance Registry System: 3-Methylpicolinonitrile(20970-75-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37
• RIDADR: 3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 20970-75-6(Hazardous Substances Data)

Usage

Description

3-Methylpicolinonitrile, also known as 3-Methyl-2-pyridinecarbonitrile, is a light beige crystalline powder with chemical properties that make it a versatile compound in various industries. It is a heterocyclic organic compound derived from picolinonitrile, featuring a methyl group attached to the third carbon position.

Uses

Used in Pharmaceutical Industry:
3-Methylpicolinonitrile is used as a chemical reagent for the synthesis of various pharmaceutical compounds. Its applications include the production of triazolo[1,5-c]pyrimidines, which are potential anti-asthma agents. These compounds have shown promise in treating asthma by targeting specific pathways involved in the disease.
Used in Oncology Research:
In the field of oncology, 3-Methylpicolinonitrile is utilized in the synthesis of α-s-tetrazine derivatives. These derivatives have demonstrated potential as anti-tumor agents, making them valuable in the development of novel cancer treatments. The compound's ability to form these derivatives contributes to its importance in cancer research and drug development.

InChI:InChI=1/C7H6N2/c1-6-3-2-4-9-7(6)5-8/h2-4H,1H3

Upstream product

• 1003-73-2 3-picoline-N-oxide 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 18368-76-8 2 chloro-3-methylpyridine 
• 151-50-8 potassium cyanide 
• 86488-30-4 N-methoxy-3-methylpyridine iodide 
• 87117-12-2 N-methoxy-3-methylpyridinium methylsulfate 
• 101870-40-0 3-methyl-pyridine-2-carbaldehyde oxime 
• 3430-17-9 2-bromo-3-picoline 
• 143-33-9 sodium cyanide 
• 773837-37-9 sodium cyanide 
• 4931-46-8 N-(3-methyl-2-pyridinyl)formamide 
• 68357-21-1 Toluene-4-sulfonic acid 2,2-dicyano-3-methyl-3,6-dihydro-2H-pyridin-1-yl ester 

Downstream Products

• 81109-80-0 2-cyano-3-(phenoxymethyl)pyridine 
• 65169-63-3 3-methyl-5-nitropyridine-2-carbonitrile 
• 15375-79-8 pyrido[2,3-d]pyridazin-8(7H)-one 
• 1029720-23-7 methyl 3-(dibromomethyl)pyridine-2-carboxylate 
• 84963-36-0 C₁₄H₁₂N₂O 

Relevant articles and documents

Method for preparing aryl primary amide by adopting metal-catalyzed one-pot method

The invention discloses a method for synthesizing aryl primary amide by adopting a metal-catalyzed one-pot method. The method comprises the steps of: taking aryl bromidess as raw materials, allowing the aryl bromidess to react with a cyanide source under the action of a palladium catalyst, substituting bromine on an aromatic ring with cyano to obtain cyano aromatic hydrocarbon, directly adding anaqueous solution of alkali into the reaction solution without aftertreatment, and carrying out hydrolysis reaction to obtain aryl primary amide. Compared with the prior art, the method for preparing aryl primary amide from the aryl bromides has the advantages of the short synthesis route, fewer reaction steps, simple operation, mild conditions, the high conversion rate, low toxicity and industrialproduction potential.

A 3 - substituted - 2 - cyano pyridine compound of preparation method

The present invention discloses a 3-substituted-2-cyanopyridine compound preparation method, which comprises: (1) mixing a solution of 3-substituted pyridine-N-oxide represented by a formula I and an acyl halide compound, and reacting to obtain a reactant; and (2) mixing the reactant I and a cyanide aqueous solution to obtain the 3-substituted-2-cyanopyridine compound represented by a formula II, wherein R is selected from methyl, halogen, hydroxy, cyano, 2-hydroxyethyl, methoxy, and 1-cyanomethyl.

COMPOUNDS USEFUL AS FAAH MODULATORS AND USES THEREOF

Compounds are disclosed that have formula (I): where A, B, L1, X, W, Y, R1, R3, and nlare as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, anxiety, depression, inflammation, cognitive disorders, weight and eating disorders, Parkinson's disease, Alzheimer's disease, spasticity, addiction, glaucoma, and others.