20790-76-5 Usage
Description
α-Amino-β-methylaminopropionic Acid Hydrochloride, also known as BMAA, is a neurotoxic non-protein amino acid isolated from the seeds of Cycas Circinalis. It is known to be an agonist at the metabotropic glutamate receptor and has been linked to the development of Guam disease, a form of amyotrophic lateral sclerosis (ALS). This white to off-white solid has gained significant attention due to its potential role in neurodegenerative diseases.
Uses
Used in Neurodegenerative Disease Research:
α-Amino-β-methylaminopropionic Acid Hydrochloride is used as a research compound for studying the mechanisms underlying neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS) and Guam disease. Its agonistic activity at the metabotropic glutamate receptor provides valuable insights into the role of excitatory neurotransmission in these conditions.
Used in Toxicological Studies:
As a neurotoxic substance, α-Amino-β-methylaminopropionic Acid Hydrochloride is utilized in toxicological research to investigate the effects of environmental toxins on the nervous system. This helps in understanding the potential risks associated with exposure to such toxins and contributes to the development of preventive measures and therapeutic strategies.
Used in Drug Development:
α-Amino-β-methylaminopropionic Acid Hydrochloride serves as a lead compound in the development of drugs targeting the metabotropic glutamate receptor. By modulating the activity of this receptor, researchers aim to develop novel therapeutic agents for the treatment of neurodegenerative diseases and other conditions related to excitatory neurotransmission.
Used in Environmental Monitoring:
α-Amino-β-methylaminopropionic Acid Hydrochloride is used as a biomarker in environmental monitoring programs to assess the presence of neurotoxic substances in the ecosystem. This helps in identifying potential sources of contamination and implementing measures to protect public health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 20790-76-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,0,7,9 and 0 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 20790-76:
(7*2)+(6*0)+(5*7)+(4*9)+(3*0)+(2*7)+(1*6)=105
105 % 10 = 5
So 20790-76-5 is a valid CAS Registry Number.
20790-76-5Relevant articles and documents
The C3-N Bond Cleavage of 2-Amino-3-(N-substituted-amino)propionic Acids Catalyzed by L-Methionine γ-Lyase
Takada, Harumi,Esaki, Nobuyoshi,Tanaka, Hidehiko,Soda, Kenji
, p. 2897 - 2902 (2007/10/02)
L-Methionine γ-lyase (EC 4.4.1.11) catalyzes α,β-elimination of L-2-amino-3-(N-methylamino)propionic acid and L-2-amino-3-(N-hydroxyethylamino)propionic acid to yield pyruvate, ammonia, and the corresponding amines.These amino acids also undergo the enzymatic β-replacament reaction with thiols to produce the corresponding S-substituted cysteines.Thus, L-methionine γ-lyase cleaves a C-N bond in addition to C-S, C-Se, and C-O bonds at the β position of amino acids by elimination and replacement reactions.A linear relationship between the reactivity, (log(Vmax/Km) and the pKa value of the conjugated acid of the leaving group has been found for Se-methyl-L-selenocysteine, S-methyl-L-cysteine, and O-methyl-L-serine.However, L-2-amino-3-(N-methylamino)propionic acid has shown lower reactivity than that expected from the pKa value of methylammonium ions.
