207680-14-6Relevant articles and documents
C7 lactyloxy-substituted taxanes
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Page/Page column 6-7, (2010/02/14)
A taxane having the formula: wherein X3 is furyl, X5 is t-butoxycarbonyl, Bz is benzoyl, and Ac is acetyl.
207680-14-6
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Basic information
- Product Name: 10-trimethylsilyl-10-deacetyl baccatin III
- Synonyms: 10-trimethylsilyl-10-deacetyl baccatin III
- CAS NO:207680-14-6
- Molecular Formula:
- Molecular Weight: 616.781
- EINECS: N/A
- Product Categories: N/A
- Mol File: 207680-14-6.mol
- Article Data: 2
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 690.6±55.0 °C(Predicted)
- Flash Point: N/A
- Appearance: N/A
- Density: 1.29±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 10-trimethylsilyl-10-deacetyl baccatin III(CAS DataBase Reference)
- NIST Chemistry Reference: 10-trimethylsilyl-10-deacetyl baccatin III(207680-14-6)
- EPA Substance Registry System: 10-trimethylsilyl-10-deacetyl baccatin III(207680-14-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 207680-14-6(Hazardous Substances Data)
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207680-14-6 Usage
Source
Derived from the Pacific yew tree, Taxus brevifolia.Role
Precursor to the potent anticancer drug paclitaxel (Taxol).Application
Used as an intermediate in the semi-synthesis of paclitaxel.Importance
Plays a crucial role in the production of paclitaxel.Medical use
Paclitaxel is widely used in the treatment of various cancers, including breast, ovarian, and lung cancer.Molecular structure
A complex molecule with a distinct and important structure.Pharmaceutical industry
A valuable component for the synthesis of paclitaxel and other taxane derivatives.Chemical modification
The presence of a trimethylsilyl group at the 10-position and the absence of an acetyl group at the 10-position differentiates it from other baccatin III derivatives.Semi-synthesis process
Involves the conversion of 10-deacetyl baccatin III into 10-trimethylsilyl-10-deacetyl baccatin III, followed by further chemical reactions to produce paclitaxel.Advantages
The use of 10-trimethylsilyl-10-deacetyl baccatin III in the semi-synthesis of paclitaxel allows for a more efficient and sustainable production process compared to extracting paclitaxel directly from the yew tree.Check Digit Verification of cas no
The CAS Registry Mumber 207680-14-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,7,6,8 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.Calculate Digit Verification of CAS Registry Number 207680-14:
(8*2)+(7*0)+(6*7)+(5*6)+(4*8)+(3*0)+(2*1)+(1*4)=126
126 % 10 = 6
So 207680-14-6 is a valid CAS Registry Number.
207680-14-6Upstream product
207680-14-6Downstream Products
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10-trimethylsilyl-10-deacetyl baccatin III
