2069-48-9

Basic information

• Product Name: 4-chloro-4'-fluorobenzophenone
• Synonyms: Methanone, (4-chlorophenyl)(4-fluorophenyl)-;(4-Chlorophenyl)(4-fluorophenyl)Methanone;4-Fluoro-4'-chlorobenzophenone;4-chloro-4'-fluorobenzophenone
• CAS NO: 2069-48-9
• Molecular Formula: C₁₃H₈ClFO
• Molecular Weight: 234.656
• Mol File: 2069-48-9.mol
• Article Data: 28

Chemical Properties

• Melting Point: 114-115 °C
• Boiling Point: 339.8 °C at 760 mmHg
• Flash Point: 159.3 °C
• Appearance: /
• Density: 1.277 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-chloro-4'-fluorobenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-4'-fluorobenzophenone(2069-48-9)
• EPA Substance Registry System: 4-chloro-4'-fluorobenzophenone(2069-48-9)

Safety Data

• Hazardous Substances Data: 2069-48-9(Hazardous Substances Data)

Usage

Chemical Properties

white crystal powder

InChI:InChI=1/C13H8ClFO/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8H

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 108-90-7 chlorobenzene 
• 462-06-6 fluorobenzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 1033-26-7 4,4'-dinitrobenzophenone 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 1765-93-1 4-fluoroboronic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 106-39-8 bromochlorobenzene 
• 637-87-6 1-Chloro-4-iodobenzene 
• 459-57-4 4-fluorobenzaldehyde 
• 21700-74-3 (p-chlorophenyl)triethoxysilane 
• 3801-53-4 (4-chlorophenyl)-4-fluorophenylmethane 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 93765-34-5 (4-Chloro-phenyl)-(4-fluoro-phenyl)-pyrimidin-5-yl-methanol 
• 42019-78-3 4-chloro-4'-hydroxybenzophenone 
• 128458-82-2 1-{4-[(4-Chloro-benzyloxy)-(4-chloro-phenyl)-methyl]-phenyl}-1H-[1,2,4]triazole 
• 128458-68-4 1-{4-[(4-Chloro-phenyl)-(2,4-dichloro-benzyloxy)-methyl]-phenyl}-1H-imidazole 
• 128458-84-4 1-{4-[(4-Chloro-phenyl)-(2,4-dichloro-benzyloxy)-methyl]-phenyl}-1H-[1,2,4]triazole 
• 1346939-72-7 (4'-butylbiphenyl-4-yl)(4'-(dimethylamino)biphenyl-4-yl)methanone 
• 1346939-70-5 (4'-(dimethylamino)biphenyl-4-yl)(4-fluorophenyl)methanone 
• 389634-34-8 4,4'-bis[4''-(4'''-chlorobenzoyl)phenoxy](hexafluoroisopropylidene)dibenzene 
• 128458-66-2 1-{4-[(4-Chloro-benzyloxy)-(4-chloro-phenyl)-methyl]-phenyl}-1H-imidazole 
• 128458-64-0 1-{4-[Benzyloxy-(4-chloro-phenyl)-methyl]-phenyl}-1H-imidazole 
• 128458-44-6 1-{4-[(4-Chloro-phenyl)-imidazol-1-yl-methyl]-phenyl}-1H-[1,2,4]triazole 
• 128458-81-1 1-{4-[Benzyloxy-(4-chloro-phenyl)-methyl]-phenyl}-1H-[1,2,4]triazole 
• 88941-49-5 α-(4-chlorophenyl)-4-(1-imidazolyl)benzenemethanol 
• 22197-31-5 4-chloro-4'-hydroxybenzophenone potassium salt 

Relevant articles and documents

AIBN initiated functionalization of the benzylic sp3 C[sbnd]H and C[sbnd]C bonds in the presence of dioxygen

A sp3 C[sbnd]H bond functionalization and C[sbnd]C bond cleavage were realized by AIBN/O2 catalyst system, providing a series of benzophenones under mild reaction conditions. The mechanistic study shows that a peroxide intermediate is involved in this transformation, and in the case of diphenylmethanes, the sp3 C[sbnd]C bond is cleaved through the peroxide rearrangement, which might provides a new way to cleave relatively strong C[sbnd]C bond and be applied to more general C[sbnd]C bond activation.

Photo-nickel dual catalytic benzoylation of aryl bromides

The dual catalytic arylation of aromatic aldehydes by aryl bromides using UV-irradiation and a nickel catalyst is reported. The reaction product serves as a photocatalyst and a hydrogen atom transfer agent for this transformation.

Pd-Catalyzed Suzuki–Miyaura Cross-Coupling of Arylboronic Acids and α-Iminonitriles through C–CN Bond Activation

A Pd-catalyzed Suzuki–Miyaura cross-coupling reaction between arylboronic acids and α-iminonitriles has been developed. The reaction proceeds through selective activation of the C–CN bond, tolerates a wide range of substituents, and delivers the versatile ketone products in moderate to excellent yields.