206551-23-7

Basic information

• Product Name: methyl 2-amino-3,5-dimethylbenzoate
• Synonyms: methyl 2-amino-3,5-dimethylbenzoate;Benzoic acid, 2-aMino-3,5-diMethyl-, Methyl ester
• CAS NO: 206551-23-7
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 206551-23-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 291.63 °C at 760 mmHg
• Flash Point: 148.734 °C
• Appearance: /
• Density: 1.105
• CAS DataBase Reference: methyl 2-amino-3,5-dimethylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-amino-3,5-dimethylbenzoate(206551-23-7)
• EPA Substance Registry System: methyl 2-amino-3,5-dimethylbenzoate(206551-23-7)

Safety Data

• Hazardous Substances Data: 206551-23-7(Hazardous Substances Data)

Usage

General Description

Methyl 2-amino-3,5-dimethylbenzoate, also known as methyl anthranilate, is an organic compound commonly used in the fragrance and flavor industry. It is a clear, colorless to pale yellow liquid with a fruity, grape-like odor. This chemical is found naturally in a variety of fruits and essential oils, including grapes, jasmine, and citronella. Methyl anthranilate is frequently used as a fragrance ingredient in perfumes, soaps, and lotions, as well as a flavoring agent in foods and beverages. It is also employed in insect repellents and as an attractant for wildlife. Additionally, it is known to be a skin and eye irritant, and inhalation or ingestion of this chemical can cause harmful effects, so it must be handled and used with caution.

Upstream product

• 67-56-1 methanol 
• 14438-32-5 3,5-dimethylanthranilic acid 
• 25081-39-4 methyl 3,5-dimethylbenzoate 

Downstream Products

• 206547-69-5 2-[(4-Methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3,5-dimethylbenzoic acid 
• 206547-68-4 2-[(4-Methoxy-benzenesulfonyl)-pyridin-3-ylmethyl-amino]-3,5-dimethyl-benzoic acid methyl ester 
• 206547-45-7 2-(4-Methoxy-benzenesulfonylamino)-3,5-dimethyl-benzoic acid methyl ester 

Relevant articles and documents

Rational design of selective inhibitors of PARP4

PARPs (PARP1-16 in humans) are a large family of ADP-ribosyltransferases (ARTs) that have diverse roles in cellular physiology and pathophysiology. Most PARP family members mediate mono-ADP-ribosylation (MARylation) of targets. The function of PARP-mediated MARylation in cells is poorly characterized, due in large part to the paucity of selective small molecule inhibitors of the catalytic activity of individual PARP enzymes. Herein we describe the rational design of selective small molecule inhibitors of PARP4 (also known as vPARP). These inhibitors are based on a quinazolin-4(3H)-one scaffold, and contain substituents at the C-8 position designed to exploit a unique threonine (Thr484, human PARP4 numbering) in the PARP4 nicotinamide sub-pocket. Our most potent analog, AEP07, which contains an iodine at the C-8 position, is at least 12-fold selective over other PARP family members. AEP07 will serve as a useful lead compound for the further development of PARP4 inhibitors that can be used to probe the cellular functions of PARP4 catalytic activity. This journal is