20610-77-9Relevant articles and documents
Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors
Sundermann, Tom R.,Benzin, Clarissa V.,Dra?i?, Tonko,Klein, Christian D.
, p. 187 - 194 (2019/05/21)
Inhibitors of the flaviviral serine proteases, which are crucial for the replication of dengue and West-Nile virus, have attracted much attention over the last years. A dibasic 4-guanidinobenzoate was previously reported as inhibitor of the dengue protease with potency in the low-micromolar range. In the present study, this lead structure was modified with the intent to explore structure-activity relationships and obtain compounds with increased drug-likeness. Substitutions of the guanidine moieties, the aromatic rings, and the ester with other functionalities were evaluated. All changes were accompanied by a loss of inhibition, indicating that the 4-guanidinobenzoate scaffold is an essential element of this compound class. Further experiments indicate that the target recognition of the compounds involves the reversible formation of a covalent adduct.
Synthesis of dinuclear complexes of rhenium(I) as potential metallomesogens
Guillevic, Marie-Andree,Light, Mark E.,Coles, Simon J.,Gelbrich, Thomas,Hursthouse, Michael B.,Bruce, Duncan W.
, p. 1437 - 1445 (2007/10/03)
Seven anisotropic diimines and their corresponding dinuclear complexes of rhenium(i) have been synthesized. The crystal and molecular structures of one of the dimines and two of the complexes were determined. In common with related inline ligands which have been synthesized previously, the new diimines were mesomorphic showing smectic C and nematic phases and, in some cases, smectic I and crystal J phases. However, none of the orthometallated, dinuclear complexes showed any liquid crystal phases. The Royal Society of Chemistry 2000.
