204764-87-4Relevant articles and documents
Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs
Nakayama, Kiyoshi,Terasawa, Hirofumi,Mitsui, Ikuo,Ohsuki, Satoru,Uoto, Kouichi,Iimura, Shin,Soga, Tsunehiko
, p. 427 - 432 (2007/10/03)
An alkylation method of docetaxel at the C-10 position has been established by a radical coupling reaction using a 10-xanthate derivative of 7-O-TES-10-deacetylbaccatin III and appropriate alkenes. In addition the cytotoxic activity of 10-alkylated docetaxel analogs was evaluated. Among these analogs, a derivative having a methoxycarbonyl group at the end of the alkyl moiety exhibited more potent cytotoxic activity than docetaxel.