204716-07-4

Basic information

• Product Name: FMOC-L-PHE(4-COCH3)
• Synonyms: Fmoc-L-4-acetylphenylalanine;FMoc-4-Acetyl-L-phenylalanine;FMOC-L-PHE(4-COCH3);(9H-Fluoren-9-yl)MethOxy]Carbonyl L-4-Acetylphe
• CAS NO: 204716-07-4
• Molecular Formula: C₂₆H₂₃NO₅
• Molecular Weight: 429.46
• Mol File: 204716-07-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 680.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.282±0.06 g/cm3(Predicted)
• PKA: 3.65±0.10(Predicted)
• CAS DataBase Reference: FMOC-L-PHE(4-COCH3)(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-L-PHE(4-COCH3)(204716-07-4)
• EPA Substance Registry System: FMOC-L-PHE(4-COCH3)(204716-07-4)

Safety Data

• Hazardous Substances Data: 204716-07-4(Hazardous Substances Data)

Usage

Description

FMOC-L-PHE(4-COCH3) is a chemical compound derived from the amino acid phenylalanine, featuring a 4-methyl-2-oxo-2H-chromen-4-yl group modification. The FMOC (9-fluorenylmethyloxycarbonyl) group acts as a protecting agent for the amino group, facilitating selective functional group modifications. The 4-COCH3 addition introduces a methyl ketone to the phenylalanine side chain, enhancing the compound's reactivity and binding characteristics. This versatile intermediate is integral in peptide and protein chemistry.

Uses

Used in Peptide and Protein Synthesis:
FMOC-L-PHE(4-COCH3) is utilized as a building block for the synthesis of peptide and protein molecules. The FMOC group serves a crucial role in protecting the amino group, enabling selective modifications of other functional groups within the molecule, which is essential for the precise construction of complex peptide and protein structures.
Used in Chemical and Biological Research:
In the field of chemical and biological research, FMOC-L-PHE(4-COCH3) is employed as a versatile intermediate. The 4-COCH3 modification allows for the exploration of how the introduction of a methyl ketone group affects the reactivity and binding properties of the compound, providing insights into the development of new chemical entities and biological probes.
Used in Pharmaceutical Development:
FMOC-L-PHE(4-COCH3) is used as a key component in the design and synthesis of pharmaceuticals. Its unique structural features can contribute to the development of drugs with specific binding affinities and selectivities, potentially leading to more effective therapeutic agents.
Used in Biochemical Assays and Diagnostics:
FMOC-L-PHE(4-COCH3) is also applied in biochemical assays and diagnostic tools. The modified phenylalanine can be incorporated into molecules that are used to study enzyme activity, develop immunoassays, or create biosensors, taking advantage of its altered reactivity and binding properties.

Upstream product

• 2361-96-8 ethyl N-acetyl-(L)-phenylalaninate 
• 63-91-2 L-phenylalanine 
• 122555-04-8 p-acetyl-L-phenylalanine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 1403957-00-5 C₁₃H₁₅NO₄ 
• 18910-27-5 para-acetylphenylalanine 

Downstream Products

• 122555-04-8 p-acetyl-L-phenylalanine 

Relevant articles and documents

MULTICYCLIC PEPTIDES AND METHODS FOR THEIR PREPARATION

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.