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2034-65-3

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2034-65-3 Usage

Description

3,7,4'-Trihydroxyflavone, commonly known as luteolin, is a naturally occurring flavonoid compound found in various plants such as celery, parsley, and chamomile. It has garnered significant attention for its potential therapeutic properties, which include anti-inflammatory, antioxidant, and anticancer effects. Luteolin's ability to inhibit cancer cell growth and induce apoptosis positions it as a promising candidate for cancer treatment. Furthermore, its neuroprotective effects suggest potential benefits for individuals with neurodegenerative diseases. 3,7,4'-TRIHYDROXYFLAVONE's wide range of health benefits and medicinal properties continue to be a subject of extensive research.

Uses

Used in Pharmaceutical Industry:
3,7,4'-Trihydroxyflavone is used as a therapeutic agent for its anti-inflammatory properties, helping to reduce inflammation in various conditions.
3,7,4'-Trihydroxyflavone is used as an antioxidant, protecting cells from oxidative stress and damage, which can contribute to aging and various diseases.
Used in Cancer Treatment:
3,7,4'-Trihydroxyflavone is used as an anticancer agent for its ability to inhibit the growth of cancer cells and induce apoptosis, making it a potential candidate for the development of cancer treatments.
Used in Neurodegenerative Disease Management:
3,7,4'-Trihydroxyflavone is used as a neuroprotective agent due to its potential to protect neurons and mitigate the effects of neurodegenerative diseases.
Used in Nutraceutical Industry:
3,7,4'-Trihydroxyflavone is used as a dietary supplement for its wide range of health benefits, including its antioxidant and anti-inflammatory properties, and its potential to support overall health and well-being.

Check Digit Verification of cas no

The CAS Registry Mumber 2034-65-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,3 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2034-65:
(6*2)+(5*0)+(4*3)+(3*4)+(2*6)+(1*5)=53
53 % 10 = 3
So 2034-65-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H10O5/c16-9-3-1-8(2-4-9)15-14(19)13(18)11-6-5-10(17)7-12(11)20-15/h1-7,16-17,19H

2034-65-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

1.2 Other means of identification

Product number -
Other names 5-Deoxykaempferol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2034-65-3 SDS

2034-65-3Relevant articles and documents

Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs

Borsari, Chiara,Lucian, Rosaria,Pozzi, Cecilia,Poehner, Ina,Henrich, Stefan,Trande, Matteo,Cordeiro-Da-silva, Anabela,Santarem, Nuno,Baptista, Catarina,Tait, Annalisa,Di Pisa, Flavio,Iacono, Lucia Dello,Landi, Giacomo,Gul, Sheraz,Wolf, Markus,Kuzikov, Maria,Ellinger, Bernhard,Reinshagen, Jeanette,Witt, Gesa,Gribbon, Philip,Kohler, Manfred,Keminer, Oliver,Behrens, Birte,Costantino, Luca,Nevado, Paloma Tejera,Bifeld, Eugenia,Eick, Julia,Clos, Joachim,Torrado, Juan,Jiménez-Antón, María D.,Corral, María J.,Alunda, José Ma,Pellati, Federica,Wade, Rebecca C.,Ferrari, Stefania,Mangani, Stefano,Costi, Maria Paola

, p. 7598 - 7616 (2016/09/04)

Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification. Flavonols were identified as hits, and a library of 16 derivatives was synthesized. Twelve compounds showed EC50 values against T. brucei below 10 μM. Four X-ray crystal structures and docking studies explained the observed structure-activity relationships. Compound 2 (3,6-dihydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one) was selected for pharmacokinetic studies. Encapsulation of compound 2 in PLGA nanoparticles or cyclodextrins resulted in lower in vitro toxicity when compared to the free compound. Combination studies with methotrexate revealed that compound 13 (3-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one) has the highest synergistic effect at concentration of 1.3 μM, 11.7-fold dose reduction index and no toxicity toward host cells. Our results provide the basis for further chemical modifications aimed at identifying novel antitrypanosomatidic agents showing higher potency toward PTR1 and increased metabolic stability.

Selective synthesis of functional alkynylmono- and -trisilanes

Hoffmann, Florian,Wagler, Joerg,Roewer, Gerhard

experimental part, p. 1133 - 1142 (2010/06/20)

The selective synthesis of functional alkynylsllanes RC=C(SiMe 2)m,-X (m = 1, 3) was investigated. Monofunctionalization with or without protecting groups gave moderate to good yields of alkynyldimethylmonosilanes RC=CMe2SiX [R = Ph, X = Cl. (1), NEt 2 (2), OMe (3), H (4), Br (5), I (6), Cp (8), C5H 4Li (10), Ph (11); R = Pr, X = Ph (12)]. Compounds 4 and 8 were converted into the (alkyne)transition-metal complexes 4-Cp2Mo 2(CO)4 (13) and 8-Co2(CO)6 (14), respectively, which were characterized by X-ray diffraction. Stepwise extension and functionalization of the silane chain starting from 1chloro-2-(diethylamino) tetramethyldisilane (Et2NMe2Si-SiMe2Cl) yielded the trisilanes Ph-(SiMe2J3-X [X = NEt2 (18), OMe (19), Cl (20), H (21), C=CPh (22), C=CPr (23)]. The synthesized compounds were characterized by NMR and IR spectroscopy, 4, 11, 13, and 14 also by UV/Vis spectroscopy.

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