2029-18-7 Usage
Description
9-Fluoro-21-iodo-16-methylpregna-1,4-diene-11,17-diol-3,20-dion is a synthetic steroid compound derived from the modification of the naturally occurring steroid, dexamethasone. It possesses a unique molecular structure with a fluorine atom at the 9th position and an iodine atom at the 21st position, along with a methyl group at the 16th position. 9-Fluoro-21-iodo-16-methylpregna-1,4-diene-11,17-diol-3,20-dion exhibits potent anti-inflammatory and immunosuppressive properties, making it a promising candidate for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
9-Fluoro-21-iodo-16-methylpregna-1,4-diene-11,17-diol-3,20-dion is used as a glucocorticoid for its anti-inflammatory and immunosuppressive effects. It is particularly effective in treating various inflammatory and autoimmune disorders, such as rheumatoid arthritis, lupus, and asthma. The presence of the fluorine and iodine atoms enhances its potency and metabolic stability, allowing for more effective control of inflammation and immune responses.
Used in Drug Delivery Systems:
To improve the bioavailability and therapeutic efficacy of 9-Fluoro-21-iodo-16-methylpregna-1,4-diene-11,17-diol-3,20-dion, various drug delivery systems have been developed. These systems, such as nanoparticles, liposomes, and hydrogels, aim to protect the compound from degradation, enhance its solubility, and provide controlled release, thereby optimizing its pharmacokinetics and therapeutic outcomes.
Used in Research Applications:
9-Fluoro-21-iodo-16-methylpregna-1,4-diene-11,17-diol-3,20-dion is also used as a research tool in the study of steroidal compounds and their biological effects. Its unique structure and potent activity make it an interesting subject for investigations into the mechanisms of action, receptor binding, and potential applications in various disease models. This knowledge can contribute to the development of new drugs and therapies based on the understanding of steroidal compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 2029-18-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,2 and 9 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 2029-18:
(6*2)+(5*0)+(4*2)+(3*9)+(2*1)+(1*8)=57
57 % 10 = 7
So 2029-18-7 is a valid CAS Registry Number.
2029-18-7Relevant articles and documents
Synthesis of new local anti-inflammatory thiosteroids based on antedrug concept
Milioni, C,Jung, L,Koch, B
, p. 947 - 951 (2007/10/02)
The synthesis and the in vitro pharmacological evaluation of a number of topical corticosteroid derivatives designed on the basis of the antedrug concept are reported.Three series of compounds were synthesized in which sulfur-containing amino acids were incorporated to the steroidal structure in the 21 position.Compounds of series I are diesters of cystine with the 21-hydroxyl groups of the corticosteroids, while series II and III contain 21-amino and 21-thio corticosteroid derivatives, respectively.The new compounds were less potent than the parent corticosteroidsin vitro.The 21-yl--S-acetylamino cysteine 13 was the most interesting compound of the series and is now under further evaluation. topical anti-inflammatory steroids / sulfur amino acids / corticosteroid activity
