2011-06-5 Usage
Description
2-(Benzyloxy)-3-methoxybenzaldehyde, also known as benzyl-o-vanillin, is an off-white to light yellow crystalline powder that can be synthesized from the reaction of o-vanillin with benzyl bromide in acetone, using K2CO3 as a base and tetra-n-butylammonium iodide as a catalyst. 2-(BENZYLOXY)-3-METHOXYBENZALDEHYDE features a dihedral angle of 23.33 (6)° between its two benzene rings and exhibits significant C-HO interactions. It has been recognized as a key reagent in the synthesis of new anticancer drugs and serves as an important pharmacophore in drug discovery, demonstrating anti-proliferative activity in HL60 leukemia cancer cells.
Uses
Used in Pharmaceutical Industry:
2-(Benzyloxy)-3-methoxybenzaldehyde is used as a key reagent for the synthesis of new anticancer drugs due to its significant anti-proliferative activity in HL60 leukemia cancer cells. Its unique chemical structure and properties make it a promising candidate for the development of novel therapeutic agents.
Used in Drug Discovery:
As an important pharmacophore, 2-(Benzyloxy)-3-methoxybenzaldehyde is utilized in drug discovery to identify and develop new compounds with potential therapeutic applications, particularly in the field of oncology.
Used in Chemical Research:
The compound's unique crystal structure and C-HO interactions make it an interesting subject for chemical research, where it can be studied to understand its properties and potential applications in various chemical and material science fields.
Check Digit Verification of cas no
The CAS Registry Mumber 2011-06-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,0,1 and 1 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2011-06:
(6*2)+(5*0)+(4*1)+(3*1)+(2*0)+(1*6)=25
25 % 10 = 5
So 2011-06-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H14O3/c1-17-14-9-5-8-13(10-16)15(14)18-11-12-6-3-2-4-7-12/h2-10H,11H2,1H3
2011-06-5Relevant articles and documents
Synthesis and structure–activity relationships of aristoyagonine derivatives as brd4 bromodomain inhibitors with x-ray co-crystal research
Jung, Kwan-Young,Kim, Yeongrin,Lee, Byung Il,Lee, Joo-Youn,Lee, Kyu Myung,Park, Chi Hoon,Park, Tae Hyun,Ryu, Seong Eon,Yoo, Minjin,Yoo, Miyoun
, (2021/06/16)
Epigenetic regulation is known to play a key role in progression of anti-cancer therapeutics. Lysine acetylation is an important mechanism in controlling gene expression. There has been increasing interest in bromodomain owing to its ability to modulate t
CARBOXYLIC ACID DERIVATIVE AS AT2R RECEPTOR ANTAGONIST
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Paragraph 0116; 0117, (2020/03/24)
The present invention relates to a compound shown in formula (II) or a pharmaceutically acceptable salt thereof and an application of the same in preparing a drug for treating a disease related to angiotensin II receptor type 2 (AT2R).(II)
Preparation technology of 1-(2-hydroxy-3-methoxyphenyl)ethanone
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Paragraph 0016-0038; 0046-0068; 0076-0088, (2017/08/27)
The invention discloses a preparation technology of 1-(2-hydroxy-3-methoxyphenyl)ethanone. Through protecting group addition, alkylation, oxidation and deprotection, 1-(2-hydroxy-3-methoxyphenyl)ethanone is prepared from o-vanillin as a raw material. The
