2007-12-7

Basic information

• Product Name: 2-naphthalen-1-yloxyacetyl chloride
• Synonyms: 2-naphthalen-1-yloxyacetyl chloride;(1-naphthyloxy)acetyl chloride;acetyl chloride, (1-naphthalenyloxy)-;2-(1-naphthyloxy)acetyl chloride;2-naphthalen-1-yloxyethanoyl chloride
• CAS NO: 2007-12-7
• Molecular Formula: C₁₂H₉ClO₂
• Molecular Weight: 220.66
• Mol File: 2007-12-7.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 339°C at 760 mmHg
• Flash Point: 125.6°C
• Appearance: /
• Density: 1.278g/cm³
• Vapor Pressure: 9.45E-05mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: 2-naphthalen-1-yloxyacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-naphthalen-1-yloxyacetyl chloride(2007-12-7)
• EPA Substance Registry System: 2-naphthalen-1-yloxyacetyl chloride(2007-12-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2007-12-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H9ClO2/c13-12(14)8-15-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H,8H2

Upstream product

• 2976-75-2 1-Naphthoxyacetic acid 
• 41643-81-6 ethyl (1-naphthalenyloxy)acetate 
• 90-15-3 α-naphthol 

Downstream Products

• 41643-45-2 N,N-Dibutyl-2-(naphthalen-1-yloxy)-acetamide 
• 61057-68-9 [2-(Naphthalen-1-yloxy)-acetylamino]-acetic acid 
• 1158842-77-3 C₄₆H₄₀N₂O₆ 
• 1164350-74-6 [2-(naphthalen-1-yloxy)acetylamino]phenylacetic acid 
• 58645-78-6 naphtho<1,2-a>-1H-furan-3-one 
• 88556-13-2 2-[2-(Naphthalen-1-yloxy)-acetylamino]-3-phenyl-propionic acid 
• 78961-69-0 1-Aziridin-1-yl-2-(naphthalen-1-yloxy)-ethanone 
• 64994-94-1 2-(2-hydroxy-phenyl)-5-(naphthalen-1-yloxy-acetyl)-5H-oxazolo[4,5-b]phenoxazine 
• 93947-58-1 N-(2-diethylaminoethyl)-2-(naphthalen-1-yloxy)acetamide 
• 64994-93-0 2-(2-chloro-phenyl)-5-(naphthalen-1-yloxy-acetyl)-5H-oxazolo[4,5-b]phenoxazine 
• 64994-92-9 2-(4-methoxy-phenyl)-5-(naphthalen-1-yloxy-acetyl)-5H-oxazolo[4,5-b]phenoxazine 

Relevant articles and documents

Benzoic acid derivative as well as preparation method and medicinal application thereof

The invention discloses a benzoic acid derivative as well as a preparation method and a pharmaceutical application thereof, and belongs to the technical field of medicines. The invention specifically discloses a benzoic acid derivative represented by a co

Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii

With multidrug resistant bacteria on the rise, novel antibiotics are becoming highly sought after. In 2008, eleven compounds were identified by high throughput screening as inhibitors of BasE, a key enzyme of the non-ribosomal peptide synthetase pathway found in Acinetobacter baumannii. Herein, we describe the preparation of four structurally similar heterocyclic lead compounds from that study, including one 1,2,5-oxadiazole. A further library of 30 analogues containing the oxadiazole moiety was then generated. All compounds were screened against Acinetobacter baumannii and their minimum inhibitory concentration data is reported, with (E)-3-(2-hydroxyphenyl)-N-(4-methyl-1,2,5-oxadiazol-3-yl)acrylamide 32 found to have an MIC of 0.5 mM. This work provides the foundation for further investigation of 1,2,5-oxadizoles as novel inhibitors of A. baumannii.

Synthesis and biological evaluation of isoflavone amide derivatives with antihyperlipidemic and preadipocyte antiproliferative activities

A series of isoflavone amides were designed with isoflavone in place of the scaffold of 2-arylbenzoxazole as cholesterol ester transfer protein (CETP) inhibitors. Twelve new compounds were synthesized, and their inhibitory activities of CETP and preadipocyte proliferation were assayed. The hypolipidemic potency of the most effective compound HY-2c was further tested in vivo by hamster. The results indicate that HY-2c exhibited favorable antihyperlipidemic and preadipocyte antiproliferative activities.