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200575-15-1

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  • 4-{{2-Ethoxy-5-[(4-methyl-1-piperazinyl)-sulfonyl]-benzoyl}-amino}-1-methyl-3-propyl-1H-pyrazole-5-carboxamide

    Cas No: 200575-15-1

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200575-15-1 Usage

Description

1H-PYRAZOLE-5-CARBOXAMIDE, 4-[[2-ETHOXY-5-[(4-METHYL-1-PIPERAZINYL)SULFONYL]BENZOYL]AMINO]-1-METHYL-3-PROPYLis a chemical compound with a complex structure, characterized by its unique arrangement of atoms and functional groups. It is an impurity found in Sildenafil, a medication used to treat erectile dysfunction.

Uses

Used in Pharmaceutical Industry:
1H-PYRAZOLE-5-CARBOXAMIDE, 4-[[2-ETHOXY-5-[(4-METHYL-1-PIPERAZINYL)SULFONYL]BENZOYL]AMINO]-1-METHYL-3-PROPYLis used as an impurity in the production of Sildenafil (S435000), an orally active selective type 5 cGMP phosphodiesterase inhibitor. Its presence is significant for quality control and ensuring the safety and efficacy of the final pharmaceutical product.

Check Digit Verification of cas no

The CAS Registry Mumber 200575-15-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,0,0,5,7 and 5 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 200575-15:
(8*2)+(7*0)+(6*0)+(5*5)+(4*7)+(3*5)+(2*1)+(1*5)=91
91 % 10 = 1
So 200575-15-1 is a valid CAS Registry Number.
InChI:InChI=1/C22H32N6O5S/c1-5-7-17-19(20(21(23)29)27(4)25-17)24-22(30)16-14-15(8-9-18(16)33-6-2)34(31,32)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H2,23,29)(H,24,30)

200575-15-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylbenzoyl]amino]-2-methyl-5-propylpyrazole-3-carboxamide

1.2 Other means of identification

Product number -
Other names 1H-Pyrazole-5-carboxamide,4-[[2-ethoxy-5-[(4-methyl-1-piperazinyl)sulfonyl]benzoyl]amino]-1-methyl-3-propyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:200575-15-1 SDS

200575-15-1Relevant articles and documents

Preparation method of sildenafil citrate

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Paragraph 0021; 0022; 0044-0047, (2021/04/07)

The invention discloses a preparation method of sildenafil. The method comprises the following steps: activating an intermediate compound B in an aprotic solvent by using thionyl chloride, reducing with 1-methyl-4-nitro-3-propyl-1H-pyrazole-5-formamide in a zinc powder-ammonium chloride system in the presence of an acid-binding agent to obtain an intermediate compound E, and condensing to obtain an intermediate compound C; and cyclizing the intermediate compound C in an alcohol solvent under an alkaline condition to prepare sildenafil. The preparation method disclosed by the invention is short in reaction time, greatly shortens the production period so as to reduce the production cost, and is simple in operation and suitable for large-scale production.

Organic synthesis in a modular robotic system driven by a chemical programming language

Steiner, Sebastian,Wolf, Jakob,Glatzel, Stefan,Andreou, Anna,Granda, Jaros?aw M.,Keenan, Graham,Hinkley, Trevor,Aragon-Camarasa, Gerardo,Kitson, Philip J.,Angelone, Davide,Cronin, Leroy

, (2018/12/14)

The synthesis of complex organic compounds is largely a manual process that is often incompletely documented. To address these shortcomings, we developed an abstraction that maps commonly reported methodological instructions into discrete steps amenable to automation. These unit operations were implemented in a modular robotic platform by using a chemical programming language that formalizes and controls the assembly of the molecules. We validated the concept by directing the automated system to synthesize three pharmaceutical compounds, diphenhydramine hydrochloride, rufinamide, and sildenafil, without any human intervention. Yields and purities of products and intermediates were comparable to or better than those achieved manually. The syntheses are captured as digital code that can be published, versioned, and transferred flexibly between platforms with no modification, thereby greatly enhancing reproducibility and reliable access to complex molecules.

A method for preparing sildenafil

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Paragraph 0023; 0025, (2017/04/08)

The invention discloses a preparation method of sildenafil and relates to the technical filed of chemical medicine synthesis. The method includes following steps: (1) carrying out a reaction between 2-ethyoxyl-5-(4-methylpiperazine-1-ylsulfonyl)benzoic acid with thionyl chloride in the presence of a catalyst to prepare an intermediate I; (2) carrying out a reaction between the intermediate I with 4-amino-1-methyl-3-propyl-1H-pyrazole-5-methanamide in the presence of an acid-binding agent to prepare an intermediate II; (3) carrying out a cyclization reaction to the intermediate II in the presence of a specific alkali to obtain a crude product of sildenafil; and (4) performing recrystallization to obtain a pure product of sildenafil. In the invention, reduced pressure distillation for removing exceeded thionyl chloride is unnecessary so that pollution is avoided. Meanwhile, the preparation method can reduce device investment, can simplify technology and can increase efficiency.

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