199170-91-7

Basic information

• Product Name: Leucine, N-acetyl-4-methyl- (9CI)
• Synonyms: Leucine, N-acetyl-4-methyl- (9CI)
• CAS NO: 199170-91-7
• Molecular Formula: C9H17NO3
• Molecular Weight: 187.24
• Mol File: 199170-91-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 371.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.051±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.66±0.10(Predicted)
• CAS DataBase Reference: Leucine, N-acetyl-4-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Leucine, N-acetyl-4-methyl- (9CI)(199170-91-7)
• EPA Substance Registry System: Leucine, N-acetyl-4-methyl- (9CI)(199170-91-7)

Safety Data

• Hazardous Substances Data: 199170-91-7(Hazardous Substances Data)

Usage

General Description

Leucine, N-acetyl-4-methyl- (9CI) is a derivative of the essential amino acid leucine, commonly found in protein-rich foods such as meat, dairy, and legumes. This chemical compound is known for its role in promoting muscle protein synthesis and aiding in muscle recovery after exercise. Additionally, N-acetyl-4-methyl-leucine has potential antioxidant properties that may protect cells from oxidative damage and inflammation. Further research is needed to fully understand the physiological effects and potential benefits of this compound in human health and performance.

Upstream product

• 57224-50-7 L-neopentylglycine 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 57224-50-7 (S)-2-Amino-4,4-dimethyl-pentanoic acid 
• 60122-72-7 4,4-Dimethyl-2(R)-aminopentanoic acid 
• 34906-87-1 4,4-dimethyl-2-oxo-pentanoic acid 
• 5429-56-1 N-Acetamidoacrylic acid 
• 38442-51-2 tert-butylmercury chloride 
• 88319-38-4 2-cyano-4,4-dimethylpentanoic acid 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 39168-28-0 (E)-2-cyano-4,4-dimethyl-pent-2-enoic acid 
• 88319-40-8 N-formyl-L-neopentylglycine 
• 88319-39-5 2-carbamoyl-4,4-dimethylpentanoic acid 

Relevant articles and documents

Direct monitoring of biocatalytic deacetylation of amino acid substrates by1H NMR reveals fine details of substrate specificity

Amino acids are key synthetic building blocks that can be prepared in an enantiopure form by biocatalytic methods. We show that thel-selective ornithine deacetylase ArgE catalyses hydrolysis of a wide-range ofN-acyl-amino acid substrates. This activity was revealed by1H NMR spectroscopy that monitored the appearance of the well resolved signal of the acetate product. Furthermore, the assay was used to probe the subtle structural selectivity of the biocatalyst using a substrate that could adopt different rotameric conformations.

Method for synthesizing chiral N-substituted-alpha-amino acid compound through chemical resolution

The invention belongs to the technical field of preparation of N-substituted-alpha-amino acid compounds, and particularly relates to a method for synthesizing a chiral N-substituted-alpha-amino acid compound through chemical resolution. The method comprises the following steps: mixing a racemate N-substituted-alpha-amino acid compound with phenylglycinol to form a salt, and adding an acid for neutralization to obtain a single-configuration chiral target product, wherein the N-substituted-alpha-amino acid compound is N-substituted-2-amino-4,4-dimethyl valeric acid, and an N-substituted amino protecting group is an alkoxycarbonyl group, an enoxycarbonyl group, an aryloxycarbonyl group or an alkylacyl group. According to the method, chiral phenylglycinol which is low in cost and stable in property is used as a resolution reagent, and N-substituted alpha-amyl amino acid can be well resolved; and R-configuration or S-configuration enantiomers are respectively obtained. The method is high inyield, good in purity, low in cost and suitable for industrial production.

PEPTIDES CONTAINING A NEOPENTYLGLYCINE RESIDUE

Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms.Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.