19728-63-3 Usage
Description
N-Cbz-L-Threonine is an N-Cbz-protected form of L-Threonine, an essential amino acid that plays a crucial role in various biological processes. It is commonly used as a feed and food additive, and is produced in mass quantities by mutant Escherichia coli strains for research and food nutrition purposes. L-Threonine can be naturally found in fish and poultry, and is incorporated in some important proteins in the human body, such as hemoglobin and insulin. N-Cbz-L-Threonine is a white to light yellow crystal powder.
Uses
Used in Pharmaceutical Industry:
N-Cbz-L-Threonine is used as a building block in the synthesis of various pharmaceutical compounds. Its N-Cbz protection allows for selective reactions and prevents unwanted side reactions, making it a valuable intermediate in the development of new drugs.
Used in Food and Nutrition Industry:
N-Cbz-L-Threonine is used as a feed and food additive to enhance the nutritional value of products. As an essential amino acid, it contributes to the overall protein content and supports the growth and maintenance of various tissues in the body.
Used in Research and Development:
N-Cbz-L-Threonine is used as a research compound to study the properties and functions of L-Threonine in biological systems. Its N-Cbz protection allows for the investigation of its role in protein synthesis and other metabolic pathways, as well as its potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 19728-63-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,7,2 and 8 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 19728-63:
(7*1)+(6*9)+(5*7)+(4*2)+(3*8)+(2*6)+(1*3)=143
143 % 10 = 3
So 19728-63-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N2O4/c1-8(15)10(11(13)16)14-12(17)18-7-9-5-3-2-4-6-9/h2-6,8,10,15H,7H2,1H3,(H2,13,16)(H,14,17)/t8-,10+/m1/s1
19728-63-3Relevant articles and documents
Incorporation of chlorinated analogues of aliphatic amino acids during cell-free protein synthesis
Stigers, Dannon J.,Watts, Zachary I.,Hennessy, James E.,Kim, Hye-Kyung,Martini, Romeo,Taylor, Matthew C.,Ozawa, Kiyoshi,Keillor, Jeffrey W.,Dixon, Nicholas E.,Easton, Christopher J.
, p. 1839 - 1841 (2011)
3-Chloro-Abu and 4-chloro-Nva are biosynthetically incorporated into E. coli peptidyl-Pro cis-trans isomerase B, as substitutes for Val and Leu, respectively. The extent of incorporation is up to ～90%, and substituted protein is catalytically active. By contrast, 4-chloro-Val is not an effective replacement for Ile.
L-threonine-linked dihydroartemisinin-fluoroquinolone conjugates, intermediates thereof, and preparation methods and uses of conjugates and intermediates
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Paragraph 0081-0086, (2019/12/08)
The invention discloses L-threonine-linked dihydroartemisinin-fluoroquinolone conjugates represented by formula I, intermediates represented by formula II, preparation methods of the compounds of formula I and formula II, and uses of the compounds of the formula I in the preparation of drugs for resisting mycobacterium tuberculosis or/and drugs for lowering blood lipids.
PROCESS AND INTERMEDIATES FOR SYNTHESIS OF PEPTIDE COMPOUNDS
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Paragraph 0176; 0177, (2019/02/13)
Disclosed is a new process and intermediates for preparing dipyrrolidine peptide compounds such as, for example, rapastinel. Advantageously, the process may be industrially scalable and cost-effective and use less toxic reagents and/or solvents. Further, the process may be used to prepare peptide compounds having improved purity.
