1972-71-0

Basic information

• Product Name: Disalicylimide
• Synonyms: Disalicylimide;2-HYDROXY-N-(2-HYDROXYBENZOYL)BENZAMIDE
• CAS NO: 1972-71-0
• Molecular Formula: C₁₄H₁₁NO₄
• Molecular Weight: 257.24144
• Mol File: 1972-71-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 203-204 °C
• Boiling Point: 503.8±50.0 °C(Predicted)
• Appearance: /
• Density: 1.382±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Very Slightly, Sonicated), Pyridine (Slightly)
• PKA: 7.48±0.30(Predicted)
• CAS DataBase Reference: Disalicylimide(CAS DataBase Reference)
• NIST Chemistry Reference: Disalicylimide(1972-71-0)
• EPA Substance Registry System: Disalicylimide(1972-71-0)

Safety Data

• Hazardous Substances Data: 1972-71-0(Hazardous Substances Data)

Usage

Description

Disalicylimide is an organic compound that serves as an impurity in Deferasirox (D228650), an orally active tridentate iron chelator.

Uses

Used in Pharmaceutical Industry:
Disalicylimide is used as an impurity in Deferasirox, an iron chelator, for the treatment of iron overload disorders. Its presence in Deferasirox is important for understanding the safety and efficacy of the drug, as impurities can have potential effects on the drug's performance and patient outcomes.

Upstream product

• 7647-01-0 hydrogenchloride 
• 65-45-2 salicylamide 
• 31295-34-8 salicylic acid:salicylate ammonium salt 
• 1369525-64-3 2-(benzyloxy)-N-[(2-hydroxyphenyl)carbonyl]benzamide 
• 4349-62-6 2-benzyloxybenzoyl chloride 
• 69-72-7 salicylic acid 
• 1218-69-5 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 
• 1441-87-8 salicyloyl chloride 
• 119-36-8 methyl salicylate 
• 118-61-6 2-hydroxy-benzoic acid ethyl ester 
• 75-44-5 phosgene 
• 118-55-8 phenyl Salicylate 

Downstream Products

• 7664-41-7 ammonia 
• 69-72-7 salicylic acid 
• 65-45-2 salicylamide 
• 1218-69-5 2-(2-hydroxyphenyl)-4H-benzo[e][1,3]oxazin-4-one 
• 1262725-38-1 C₂₂H₁₄N₄O₂ 
• 1262725-37-0 C₂₃H₁₇N₃O₄ 
• 1262725-40-5 C₂₂H₁₅N₃O₄ 
• 1262725-42-7 C₂₈H₂₇N₃O₄ 
• 1262725-43-8 C₃₀H₃₁N₃O₄ 
• 1262725-44-9 C₃₁H₃₃N₃O₄ 
• 201530-41-8 deferasirox 
• 74619-50-4 3,5-bis-(o-hydroxyphenyl)-1H-1,2,4-triazole 
• 38370-04-6 2,4-Bis(2-hydroxyphenyl)-6-phenyl-1,3,5-triazine 
• 86245-88-7 1-phenyl-3,5-bis(o-acetoxyphenyl)-1,2,4-triazole 

Relevant articles and documents

Proton transfer triggered proton transfer: A self-assisted twin excited state intramolecular proton transfer

The double excited state intramolecular proton transfer (ESIPT) of 3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazole (bis-HPTA), a molecule possessing two intramolecular hydrogen bonded donor-acceptor pairs, has been investigated. The molecule undergoes not only

Synthesis and characterization of related substances of deferasirox, an iron (Fe3+) chelating agent

Deferasirox is an orally active iron chelating agent, and during process development for deferasirox, we observed six related substances (impurities), namely deferasirox methyl ester, deferasirox salicylyl derivative, deferasirox ethyl ester, deferasirox methoxy carbonyl derivative, bis(salicyl)imide, and deferasirox-2-isomer. The present work describes the detection, origin, synthesis, and characterization of these related substances.