195447-72-4

Basic information

• Product Name: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide
• Synonyms: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide;2-Bromo-N-(4,5-dimethyl-3-isoxazolyl)benzenesulfonamide;N-(4,5-dimethyl-3-isoxazolyl)-2-bromobenzenesulfonamide;Benzenesulfonamide, 2-bromo-N-(4,5-dimethyl-3-isoxazolyl)-
• CAS NO: 195447-72-4
• Molecular Formula: C₁₁H₁₁BrN₂O₃S
• Molecular Weight: 331.18564
• Mol File: 195447-72-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 468.832°C at 760 mmHg
• Flash Point: 237.341°C
• Appearance: /
• Density: 1.629g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide(195447-72-4)
• EPA Substance Registry System: 2-broMo-N-(4,5-diMethylisoxazol-3-yl)benzenesulfonaMide(195447-72-4)

Safety Data

• Hazardous Substances Data: 195447-72-4(Hazardous Substances Data)

Usage

Description

2-bromo-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide is a chemical compound with the molecular formula C11H12BrN3O2S. It is a sulfonamide derivative that incorporates a bromine atom and an isoxazole moiety, known for its potential applications in the pharmaceutical and agrochemical industries due to its antibacterial and antifungal properties.

Uses

Used in Pharmaceutical Industry:
2-bromo-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide is used as a building block in the synthesis of pharmaceuticals for its antibacterial and antifungal properties, contributing to the development of new medications to combat resistant strains of bacteria and fungi.
Used in Agrochemical Industry:
In the agrochemical sector, 2-bromo-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide is utilized as a component in the creation of pesticides and fungicides, leveraging its antimicrobial properties to protect crops from diseases and pests.
Used in Research:
2-bromo-N-(4,5-dimethylisoxazol-3-yl)benzenesulfonamide also serves as a research tool to study the structure and function of biological molecules, aiding scientists in understanding complex biological processes and the design of more effective drugs.

InChI:InChI=1/C11H11BrN2O3S/c1-7-8(2)17-13-11(7)14-18(15,16)10-6-4-3-5-9(10)12/h3-6H,1-2H3,(H,13,14)

Upstream product

• 2905-25-1 o-bromobenzenesulfonyl chloride 
• 144-55-8 sodium hydrogencarbonate 
• 13999-39-8 4,5-dimethyl-1,2-oxazol-3-amine 
• 195447-71-3 4,5-dimethyl-3-isoxazolamine hydrochloride 

Downstream Products

• 1201936-87-9 N-(4,5-Dimethyl-3-isoxazolyl)-N-[[(2-trimethylsilyl)ethoxy]methyl]-2-bromobenzenesulfonamide 
• 210891-04-6 Edonentan 
• 195447-74-6 N-(4,5-dimethyl-3-isoxazolyl)-2'-formyl-N-[(2-methoxyethoxy)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 210891-13-7 N-(4,5-dimethyl-3-isoxazolyl)-2'-[(methylamino)methyl]-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 210891-12-6 N-(4,5-Dimethyl-3-isoxazolyl)-2'-formyl-4'-(2-oxazolyl)[1,1'-biphenyl]-2-sulfonamide 
• 254746-77-5 [2-[[(4,5-dimethyl-3-isoxazolyl)[(2-methoxyethoxy)methyl]amino]-sulfonyl]phenyl]boronic acid 
• 195447-73-5 2-Bromo-N-(4,5-dimethyl-3-isoxazolyl)-N-[(2-methoxyethoxy)methyl]-benzenesulfonamide 

Relevant articles and documents

Dual antagonist of angiotensin II receptor and endothelin receptor

The invention relates to dual antagonists of an angiotensin II receptor and an endothelin receptor. Specifically, the invention provides a compound represented by a formula I and a preparation method thereof. The compound can be used for treating diseases

Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4- (2-oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ETA s

We have previously disclosed the selective ETA receptor antagonist N-(3,4-dimethyl-5-isoxazolyl)-4′-(2-oxazolyl)[1,1′- biphenyl]-2-sulfonamide (1, BMS-193884) as a clinical development candidate. Additional SAR studies at the 2′-position of 1 l

Substituted biphenyl isoxazole sulfonamides

Compounds of the formula STR1 inhibit the activity of endothelin. The symbols are defined as follows: R1, R2, R3 and R4 are each directly bonded to a ring carbon and are each independently (a) hydrogen; (b) alkyl, alkenyl, alkynyl, alkoxy, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aryloxy, aralkyl or aralkoxy, any of which may be substituted with Z1, Z2 and Z3 ; (c) halo; (d) hydroxyl; (e) cyano; (f) nitro; (g) --C(O)H or --C(O)R5 ; (h) --CO2 H or --CO2 R5 ; (i) --Z4 --NR6 R7 ; (j) --Z4 --N(R10)--Z5 --NR8 R9 ; or (k) R3 and R4 together may also be alkylene or alkenylene, either of which may be substituted with Z1, Z2 and Z3, completing a 4- to 8-membered saturated, unsaturated or aromatic ring together with the carbon atoms to which they are attached; and the remaining symbols are as defined in the specification.