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19499-60-6

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19499-60-6 Usage

Description

N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE, with the chemical formula C8H10ClN2O2, is a white to off-white crystalline solid that exhibits solubility in both water and organic solvents. It is a versatile chemical compound that serves as a fundamental building block in various synthesis processes.

Uses

Used in Pharmaceutical Synthesis:
N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of amine and amide derivatives, which are crucial in the development of various medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE is utilized as a building block in the creation of agrochemicals, playing a significant role in the development of substances that contribute to crop protection and enhancement of agricultural yields.
Used in Organic Synthesis as a Reagent:
N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE is employed as a reagent in organic synthesis, particularly for the preparation of amine and amide derivatives, which are essential in the formation of complex organic molecules.
Used in the Production of Dyes and Pigments:
This chemical compound is also used in the production of dyes and pigments, where its properties contribute to the coloration and stability of these products in various applications.
Used in the Manufacture of Specialty Chemicals:
N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE finds application in the manufacture of specialty chemicals, where its unique characteristics are leveraged to produce high-quality and specialized chemical products.
Safety Precautions:
It is important to handle N-METHYL-N-(4-NITROBENZYL)AMINE HYDROCHLORIDE with care due to its potential harmful effects if ingested, inhaled, or absorbed through the skin. Adequate safety measures should be implemented during its use to ensure the well-being of individuals working with this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 19499-60-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,9 and 9 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 19499-60:
(7*1)+(6*9)+(5*4)+(4*9)+(3*9)+(2*6)+(1*0)=156
156 % 10 = 6
So 19499-60-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2O2.ClH/c1-9-6-7-2-4-8(5-3-7)10(11)12;/h2-5,9H,6H2,1H3;1H

19499-60-6Relevant articles and documents

Design, Synthesis, and Biological Evaluation of Novel 3-Aminomethylindole Derivatives as Potential Multifunctional Anti-Inflammatory and Neurotrophic Agents

Wang, Wei-Wei,Liu, Ting,Lv, Yu-Meng,Zhang, Wu-Yang,Liu, Zhi-Gang,Gao, Jin-Ming,Li, Ding

, p. 1593 - 1605 (2021/05/31)

The development of multifunctional molecules that are able to simultaneously interact with several pathological components has been considered as a solution to treat the complex pathologies of neurodegenerative diseases. Herein, a series of aminomethylindole derivatives were synthesized, and evaluation of their application for antineuroinflammation and promoting neurite outgrowth was disclosed. Our initial screening showed that most of the compounds potently inhibited lipopolysaccharide (LPS)-stimulated production of NO in microglial cells and potentiated the action of NGF to promote neurite outgrowth of PC12 cells. Interestingly, with outstanding NO/TNF-α production inhibition and neurite outgrowth-promoting activities, compounds 8c and 8g were capable of rescuing cells after injury by H2O2. Their antineuroinflammatory effects were associated with the downregulation of the LPS-induced expression of the inflammatory mediators inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Western blotting and immunofluorescence assay results indicated that the mechanism of their antineuroinflammatory actions involved suppression of the MAPK/NF-κB signal pathways. Further studies revealed that another important reason for the high comprehensive antineuroinflammatory activity was the anti-COX-2 capabilities of the compounds. All these results suggest that the potential biochemical multifunctional profiles of the aminomethylindole derivatives provide a new sight for the treatment of neurodegenerative diseases.

Epoxide-Mediated Stevens Rearrangements of α-Amino-Acid-Derived Tertiary Allylic, Propargylic, and Benzylic Amines: Convenient Access to Polysubstituted Morpholin-2-ones

Jin, You-Xiang,Yu, Bang-Kui,Qin, Si-Ping,Tian, Shi-Kai

, p. 5169 - 5172 (2019/03/28)

A new strategy has been established for the synthesis of polysubstituted morpholin-2-ones through Stevens rearrangements of tertiary amines via in situ activation with epoxides. A range of α-amino acid-derived tertiary allylic, propargylic, and benzylic amines reacted with epoxides in the presence of zinc halide catalysts to afford structurally diverse allyl-, allenyl-, and benzyl-substituted morpholin-2-ones, respectively, in moderate-to-good yields with high regioselectivity. The process involves [2,3]- and [1,2]-Stevens rearrangements of quaternary ammonium ylide intermediates and constitutes a very convenient method to prepare polysubstituted morpholin-2-ones through tandem formation of C?N, C?O, and C?C bonds. Moreover, replacing epoxides with aziridines permitted the synthesis of polysubstituted piperazin-2-ones.

Novel chiral bis-phosphoramides as organocatalysts for tetrachlorosilane-mediated reactions

Rossi, Sergio,Ziliani, Marco,Annunziata, Rita,Benaglia, Maurizio

supporting information, (2018/01/12)

The formation of novel chiral bidentate phosphoroamides structures able to promote Lewis base-catalyzed Lewis acid-mediated reactions was investigated. Two different classes of phosphoroamides were synthetized: the first class presents a phthalic acid/pri

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