19430-83-2 Usage
Description
3,4'-Diaminodiphenylmethane, also known as Methylene dianiline or MDA, is a chemical compound characterized by two primary amine groups connected by a central benzene-derived moiety. It is extensively used in various industrial manufacturing processes, including the production of polyurethane foams, epoxy resins, and spandex fibers. MDA is typically found as a light yellow to dark brown solid or crystal and is highly toxic, posing several health hazards such as skin and eye irritation, liver and kidney damage, and mutagenic effects. Due to its potential carcinogenic properties, it is crucial to implement safety measures when handling this compound.
Uses
Used in Polyurethane Foam Production:
3,4'-Diaminodiphenylmethane is used as a key chemical intermediate for the synthesis of polyurethane foams, which are versatile materials employed in various applications such as furniture, bedding, insulation, and automotive seating. 3,4'-DIAMINODIPHENYLMETHANE contributes to the formation of the foam's structure and properties.
Used in Epoxy Resin Manufacturing:
In the production of epoxy resins, 3,4'-Diaminodiphenylmethane serves as a curing agent, which is essential for hardening the resin and providing the desired mechanical and chemical properties. Epoxy resins are widely used in coatings, adhesives, electrical laminates, and composite materials.
Used in Spandex Fiber Industry:
3,4'-Diaminodiphenylmethane is used as a monomer in the polymerization process to produce spandex fibers, which are known for their exceptional elasticity and are used in the textile industry for manufacturing stretchable fabrics and garments.
Used in Other Industrial Manufacturing Procedures:
Beyond the mentioned applications, 3,4'-Diaminodiphenylmethane is also utilized in various other industrial processes, where its chemical properties are harnessed to achieve specific outcomes in the final products. 3,4'-DIAMINODIPHENYLMETHANE's versatility and reactivity make it a valuable component in the synthesis of different materials and compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 19430-83-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,4,3 and 0 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 19430-83:
(7*1)+(6*9)+(5*4)+(4*3)+(3*0)+(2*8)+(1*3)=112
112 % 10 = 2
So 19430-83-2 is a valid CAS Registry Number.
19430-83-2Relevant articles and documents
Guanidinium-based derivatives: Searching for new kinase inhibitors
Diez-Cecilia, Elena,Kelly, Brendan,Perez, Concepcion,Zisterer, Daniela M.,Nevin, Daniel K.,Lloyd, David G.,Rozas, Isabel
, p. 427 - 441 (2014/06/09)
Considering the structural similarities between the kinase inhibitor sorafenib and 4,4′-bis-guanidinium derivatives previously prepared by Rozas and co., which display interesting cytotoxicity in cancer cells, we have studied whether this activity could result from kinase inhibition. Five new families have been prepared consisting of unsubstituted and aryl-substituted 3,4′-bis-guanidiniums, 3,4′-bis-2-aminoimidazolinium and 3-acetamide-4′-(4-chloro-3-trifluoromethylphenyl)guanidinium derivatives. Cytotoxicity (measuring the IC50 values) and apoptosis studies in human HL-60 promyelocytic leukemia cells were carried out for these compounds. Additionally, their potential inhibitory effect was explored on a panel of kinases known to be involved in apoptotic pathways. The previously prepared cytotoxic 4,4′-bis-guanidiniums did not inhibit any of these kinases; however, some of the novel 3,4′-substituted derivatives showed a high percentage inhibition of RAF-1/MEK-1, for which the potential mode of binding was evaluated by docking studies. The interesting antitumour properties showed by these compounds open up new exciting lines of investigation for kinase inhibitors as anticancer agents and also highlights the relevance of the guanidinium moiety for protein kinase inhibitors chemical design.
