193361-04-5Relevant articles and documents
Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides
Kuriyama, Masami,Yano, Gemba,Kiba, Hirotoshi,Morimoto, Tetsuro,Yamamoto, Kosuke,Demizu, Yosuke,Onomura, Osamu
, p. 1552 - 1557 (2019)
The palladium-catalyzed deuterodechlorination of alkenyl chlorides has been developed, and a variety of deuterated alkenes were synthesized with precise control of the deuterium incorporation. This catalytic process tolerates heterocyclic moieties and frameworks derived from bioactive agents. In addition to the double incorporation of deuterium, the gram-scale synthesis of a deuterated iminostilbene unit including a core substructure of carbamazepine was achieved in a high yield with an excellent degree of deuteration.
Modified shapiro reactions with bismesitylmagnesium as an efficient base reagent
Kerr, William J.,Morrison, Angus J.,Pazicky, Marek,Weber, Tina
, p. 2250 - 2253 (2012/06/30)
Bismesitylmagnesium has been shown to successfully mediate the Shapiro reaction. A range of tosylhydrazones has been subjected to the developed system, which furnishes exceptionally high incorporation of the introduced electrophiles and good yields of the functionalized styrenes. At conveniently accessible temperatures and with a comparably small excess of base reagent, this protocol offers an efficient alternative to the lithium-mediated process. Importantly, 1.05 equiv of Weinreb amides are sufficient to obtain aryl enones in good yields.
Nickel-catalyzed regioselective hydroalkynylation of styrenes: Improved catalyst system, reaction scope, and mechanism
Shirakura, Masamichi,Suginome, Michinori
supporting information; experimental part, p. 523 - 526 (2009/07/11)
(Chemical Equation Presented) Addition of the sp-C H bond of triisopropylsilylacelylene to the carbon-carbon double bonds of styrenes bearing functional groups proceeded efficiently at room temperature in the presence of 3 mol % of Ni(cod)2 wit
