19294-04-3

Basic information

• Product Name: 3,5-Bis(bromomethyl)toluene
• Synonyms: 3,5-BIS(BROMOMETHYL)METHYLBENZENE;3,5-BIS(BROMOMETHYL)TOLUENE;1,3-BIS(BROMOMETHYL)-5-METHYLBENZENE;à,à'-dibromomesitylene;3,5-BIS(BROMOMENTHY) METHYLBENZENE;1,3-BIS(BROMOMETHYL)-5-METHYLBENZENE,98%;Benzene, 1,3-bis(bromomethyl)-5-methyl-;1,3-Bis(bromomethyl)-5-methylbenzene, alpha,alpha'-Dibromomesitylene
• CAS NO: 19294-04-3
• Molecular Formula: C₉H₁₀Br₂
• Molecular Weight: 277.98
• EINECS: 243-034-3
• Product Categories: API intermediates
• Mol File: 19294-04-3.mol
• Article Data: 14

Chemical Properties

• Melting Point: 64-67℃
• Boiling Point: 293.3°Cat760mmHg
• Flash Point: 149.8°C
• Appearance: /
• Density: 1.687g/cm³
• Vapor Pressure: 2.08mmHg at 25°C
• Refractive Index: 1.43
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Sparingly), Methanol (Sparingly)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 3,5-Bis(bromomethyl)toluene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Bis(bromomethyl)toluene(19294-04-3)
• EPA Substance Registry System: 3,5-Bis(bromomethyl)toluene(19294-04-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 1759
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 19294-04-3(Hazardous Substances Data)

Usage

Uses

1,?3-?Bis(bromomethyl)?-?5-?methylbenzene is a reagent used in the synthesis of sphingosine kinase 2 inhibitors. Anastrozole 1,3-Dibromomethyl Impurity

InChI:InChI=1/C10H20/c1-3-5-7-9-10-8-6-4-2/h7,9H,3-6,8,10H2,1-2H3/b9-7+

Upstream product

• 108-67-8 1,3,5-trimethyl-benzene 
• 27129-86-8 1-bromomethyl-3,5-dimethylbenzene 
• 27711-63-3 1,3-bis-(hydroxymethyl)-5-methylbenzene 

Downstream Products

• 854752-44-6 1,3-bis-acetoxymethyl-5-methyl-benzene 
• 120511-74-2 (3-cyanomethyl-5-methyl-phenyl)-acetonitrile 
• 357262-27-2 (μ-SC(CH3)3)(μ-1-SeCH2-3-BrCH2-5-MeC6H3)(Fe2(CO)6)2(μ4-Se) 
• 357262-28-3 ((μ-SC(CH3)3)(Fe2(CO)6)2(μ4-Se))2(μ-1-SeCH2-5-MeC6H3CH2Se-3-μ) 

Relevant articles and documents

Distinct structures of inorganic-organic supramolecular assemblies based on discrete metallocyclic complexes incorporating flexible imidazole ligands: Syntheses, crystal structures and properties

Three new interesting discrete dinuclear metallocyclic complexes, namely, {[Pd2(1)4](NO3)4· 2DMSO· 2H2O}n (4), [Pd2(2) 2Br4]n (5), and {[Pd2(3) 2Cl4]·4DMSO}n (6) have been successfully synthesized by the reaction of flexible exo-bidentate imidazole-containing ligands 1, 3-bis(imidazol-1-ylmethyl)benzene (1), 1, 3-bis(imidazol-1-ylmethyl)- 5-methylbenzene (2), and 2, 6-bis(imidazol-1-ylmethyl)-4-tert-butyl-phenol (3) with corresponding palladium salts. All these complexes were characterized by NMR spectroscopy in combination with elemental analysis, powder X-ray diffraction (PXRD), single-crystal X-ray diffraction, and thermal gravimetric analysis (TGA), respectively. Though all three complexes involve the similar supramolecular building blocks [2+2] metallocyclic units, under the inducement effect of the organic ligands, compounds 4-6 exhibit delicate geometric diversification of the resulting high-dimensional inorganic-organic supramolecular assemblies (e.g., [4+2] lantern-like cage structure, 1D channel, and 2D undulating framework, respectively). Furthermore, these results demonstrate that the secondary interactions such as intermolecular π ··· π stacking interactions and hydrogen bonds could play important roles in the aspect of linking low-dimensional entities into high-dimensional supramolecular frameworks.

Self-assembly from metal-organic vesicles to globular networks: Metallogel-mediated phenylation of indole with phenyl boronic acid

Self-assembly of the conformationally flexible bismethylimidazolyl ligands with Pd(OAc)2 is described. Depending on whether the ligands provide the hydrogen bonding donor, a switching of metal-organic vesicles to globular networks gelating solvents is achieved. The metallogels exhibit catalytic activity for the cross-coupling of indole with phenyl boronic acid.

An efficient synthesis of 3,5-bis(2-cyanoisopropyl)toluene

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