19169-90-5 Usage
Description
BROMOMETHYL PHENYL SULFONE is an organic compound that is formed through the reaction of bromomethyl phenyl sulfone with potassium thiophenoxide in dimethyl formamide, resulting in phenylthiomethyl phenyl sulfone. It can undergo disproportionation with KOH in DMSO at room temperature, yielding methyl phenyl sulfone and dibromomethyl phenyl sulfone. BROMOMETHYL PHENYL SULFONE has potential applications in various industries due to its unique chemical properties.
Uses
Used in Chemical Synthesis:
BROMOMETHYL PHENYL SULFONE is used as an intermediate in the synthesis of various organic compounds for [application reason] its ability to undergo reactions with other chemicals to form new products.
Used in Pharmaceutical Industry:
BROMOMETHYL PHENYL SULFONE is used as a building block for the development of new pharmaceutical compounds for [application reason] its potential to be incorporated into the structure of drugs with specific therapeutic properties.
Used in Material Science:
BROMOMETHYL PHENYL SULFONE is used as a component in the development of advanced materials for [application reason] its unique chemical properties that can contribute to the creation of materials with specific characteristics.
Used in Research and Development:
BROMOMETHYL PHENYL SULFONE is used as a research compound for [application reason] its potential to provide insights into the behavior of similar organic compounds and their interactions with other chemicals.
Check Digit Verification of cas no
The CAS Registry Mumber 19169-90-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,9,1,6 and 9 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 19169-90:
(7*1)+(6*9)+(5*1)+(4*6)+(3*9)+(2*9)+(1*0)=135
135 % 10 = 5
So 19169-90-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H7BrO2S/c8-6-11(9,10)7-4-2-1-3-5-7/h1-5H,6H2
19169-90-5Relevant articles and documents
Controlled α-mono- and α,α-di-halogenation of alkyl sulfones using reagent-solvent halogen bonding
Poteat, Christopher M.,Lindsay, Vincent N. G.
supporting information, p. 2912 - 2915 (2019/03/17)
The direct and selective α-mono-bromination of alkyl sulfones was achieved through base-mediated electrophilic halogenation. The appropriate combination of solvent and electrophilic bromine source was found to be critical to control the nature of the products formed, where reagent-solvent halogen bonding is proposed to control the selectivity via alteration of the effective size of the electrophilic bromine source. Conversely, the α,α-di-brominated sulfones were selectively obtained in good yields following polyhalogenation followed by selective de-halogenation during workup. Both procedures can be applied on gram scale, and the mono-halogenation was successfully extended to the fully selective α-chlorination, α-iodination and α-fluorination of alkyl sulfones.
THE PREPARATION, SPECTRAL PROPERTIES, STRUCTURES, AND BASE-INDUCED CLEAVAGE REACTIONS OF SOME α-HALO-β-KETOSULFONES
Grosset, Stuart J.,Dubey, Pramod K.,Gill, Glen H.,Cameron, Stanley T.,Gardner, Patrick A.
, p. 798 - 807 (2007/10/02)
The halogenation of β-ketosulfones such as α-methylsulfonylacetophenone (1) and benzenesulfonylacetone (10) can be effected with sulfuryl chloride or pyridinium bromide perbromide.Regiochemical control can be achieved by control of stoichiometry and/or the reaction conditions.Detailed 1H and 13C nmr, and mass spectra are recorded for a series of halogenated β-ketosulfones, together with structures by X-ray crystallography for 1, 2-chloro-2-methylsulfonyl-1-phenylethanone (2), chloromethyl methyl sulfone (4), and α-chloroacetophenone (21).Results from these studies are used to suggest a reason for the difficulty associated with substitution reactions of α-halosulfones.
