191110-49-3Relevant articles and documents
PROGRANULIN MODULATORS AND METHODS OF USING THE SAME
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Paragraph 0516, (2021/04/30)
Provided herein are compounds of formula (I) that modulate progranulin and methods of using the compounds in progranulin- associated disorders, such as Frontotemperal lobe dementia (FTLD).
PROCESS SIMPLIFICATION FOR PRECURSOR COMPOUND
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Page/Page column 13-14, (2012/07/13)
The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the invention relates to a process for preparation of a precursor useful in the preparation of the [18F]-1-amino-3- fluorocyclobutanecarboxyiic acid ([18F] FACBC) PET tracer.
Synthesis of [F-18]-1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC): A pet tracer for tumor delineation
Shoup, Timothy M.,Goodman, Mark M.
, p. 215 - 225 (2007/10/03)
Fluorine-18 labeled 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), a new tumor-avid amino acid, was synthesized for positron emission tomography. [18F]FACBC was prepared with high specific activity by nucleophilic displacement with an o