1908442-13-6 Usage
Description
3-(t-butyl)-4-(2,6-dimethoxyphenyl)-2-(2,4,6-triisopropylbenzyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole is a complex organic compound with a unique molecular structure. It is characterized by its t-butyl, dimethoxyphenyl, and triisopropylbenzyl groups, which contribute to its chemical properties and potential applications.
Uses
Used in Pharmaceutical Industry:
3-(t-butyl)-4-(2,6-dimethoxyphenyl)-2-(2,4,6-triisopropylbenzyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole is used as a catalyst for Suzuki-Miyaura cross-couplings, a type of chemical reaction widely employed in the synthesis of various pharmaceutical compounds. Its use in this application is due to its ability to form a 1:1 complex with Pd(OAc)2, creating a pre-catalyst that enables the reaction to occur under micellar catalysis in water at room temperature.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3-(t-butyl)-4-(2,6-dimethoxyphenyl)-2-(2,4,6-triisopropylbenzyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole is used as a catalyst to facilitate Suzuki-Miyaura cross-couplings. This application takes advantage of its ability to form a pre-catalyst with Pd(OAc)2, allowing for efficient and selective synthesis of various organic compounds.
Used in Research and Development:
3-(t-butyl)-4-(2,6-dimethoxyphenyl)-2-(2,4,6-triisopropylbenzyl)-2,3-dihydrobenzo[d][1,3]oxaphosphole is also utilized in research and development settings, where its unique molecular structure and catalytic properties can be explored for potential applications in various fields, including materials science, pharmaceuticals, and chemical synthesis.
Enhanced for Catalytic Efficiency:
This product has been specifically enhanced for improved catalytic efficiency, making it a valuable tool in various chemical reactions and processes. Its enhanced properties allow for more efficient and selective reactions, leading to better yields and reduced waste in the synthesis of target compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1908442-13-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,9,0,8,4,4 and 2 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1908442-13:
(9*1)+(8*9)+(7*0)+(6*8)+(5*4)+(4*4)+(3*2)+(2*1)+(1*3)=176
176 % 10 = 6
So 1908442-13-6 is a valid CAS Registry Number.
1908442-13-6Relevant articles and documents
Computationally Assisted Mechanistic Investigation and Development of Pd-Catalyzed Asymmetric Suzuki-Miyaura and Negishi Cross-Coupling Reactions for Tetra- ortho-Substituted Biaryl Synthesis
Patel, Nitinchandra D.,Sieber, Joshua D.,Tcyrulnikov, Sergei,Simmons, Bryan J.,Rivalti, Daniel,Duvvuri, Krishnaja,Zhang, Yongda,Gao, Donghong A.,Fandrick, Keith R.,Haddad, Nizar,Lao, Kendricks So,Mangunuru, Hari P. R.,Biswas, Soumik,Qu, Bo,Grinberg, Nelu,Pennino, Scott,Lee, Heewon,Song, Jinhua J.,Gupton, B. Frank,Garg, Neil K.,Kozlowski, Marisa C.,Senanayake, Chris H.
, p. 10190 - 10209 (2018/10/20)
Metal-catalyzed cross-coupling reactions are extensively employed in both academia and industry for the synthesis of biaryl derivatives for applications to both medicine and material science. Application of these methods to prepare tetra-ortho-substituted
HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature
Handa, Sachin,Andersson, Martin P.,Gallou, Fabrice,Reilly, John,Lipshutz, Bruce H.
, p. 4914 - 4918 (2016/04/26)
The new monophosphine ligand HandaPhos has been identified such that when complexed in a 1:1 ratio with Pd(OAc)2, enables Pd-catalyzed cross-couplings to be run using ≤1000 ppm of this pre-catalyst. Applications to Suzuki-Miyaura reactions involving highly funtionalized reaction partners are demonstrated, all run using environmentally benign nanoreactors in water at ambient temperatures.
