190330-64-4Relevant articles and documents
NUCLEIC ACID-BINDING PHOTOPROBES AND USES THEREOF
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Paragraph 0043, (2019/06/17)
The present invention relates to photoactivatable compounds and methods of use thereof for determining binding site and other structural information about RNA transcripts. The invention also provides methods of identifying RNA transcripts that bind compounds and are thus druggable, methods of screening drug candidates, and methods of determining drug binding sites and/or accessible or reactive sites on a target RNA.
Compound containing fluorene ring structure, and application thereof
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Paragraph 0184, (2019/10/04)
The present invention discloses a compound containing a fluorene ring structure, and an application thereof. The compound containing the fluorene ring structure of the present invention contains a hydroxyl group, an amino group, a substituted amino group and an active group, and can be used as an amino acid or peptide C-terminal protection reagent. The above peptide using a protective carrier has a high reaction speed and a high reagent utilization rate in a suitable solvent system when used in a reaction; post-treatment is carried out by simple liquid-liquid extraction separation to achieve effective purification, so the product with a high purity is finally obtained; and the compound has a small solubility change in the synthesis process, and the operating flow has high versatility, so a synthesis method of the compound can be developed into a universal production method.
INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS
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Paragraph 0381; 0382, (2018/04/21)
The present disclosure relates to compounds and a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing the compounds, and processes for their preparation. The disclosure also relates to the use of the compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.
