189950-66-1 Usage
Description
AC-DEVD-PNA, also known as N-Acetyl-L-α-aspartyl-L-α-glutamyl-L-valyl-N-(4-nitrophenyl)-L-asparagine, is a para-nitroaniline chromophore that is specifically cleaved by caspase enzymes. It is a valuable tool in the study of apoptosis and caspase activity due to its ability to provide a colorimetric readout of caspase activity.
Uses
Used in Research and Development:
AC-DEVD-PNA is used as a chromogenic substrate for Caspase 3 and CCP-32, which are important enzymes involved in the execution of apoptosis. This application is crucial for understanding the mechanisms of cell death and developing potential therapeutic strategies for various diseases.
Used in Diagnostics:
AC-DEVD-PNA is used as a diagnostic tool for determining caspase-3 and caspase-8 activities in liver tissue homogenates, aortic vascular smooth muscle cells, and neuroblastoma cell lines. This helps in the assessment of apoptosis-related conditions and the effectiveness of treatments targeting caspase activity.
Used in Pharmaceutical Industry:
AC-DEVD-PNA is used in the development of drugs targeting caspase enzymes, which play a significant role in apoptosis. By understanding the interaction between AC-DEVD-PNA and caspase enzymes, researchers can design more effective drugs for treating diseases where apoptosis is a critical factor.
Biochem/physiol Actions
Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Check Digit Verification of cas no
The CAS Registry Mumber 189950-66-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,9,5 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 189950-66:
(8*1)+(7*8)+(6*9)+(5*9)+(4*5)+(3*0)+(2*6)+(1*6)=201
201 % 10 = 1
So 189950-66-1 is a valid CAS Registry Number.
