189400-21-3

Basic information

• Product Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester
• Synonyms: Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-(-1H-tetrazol-5-ylbiphenyl-4-yl);OlMesartan Ethyl Ester N1-Trityl Analog;Ethyl 4-(1-hydroxy-1-Methylethyl)-2-propyl-1...;4-(1-Hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-;4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl];1H-Imidazole-5-carboxylic acid,4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H(or 2H)-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-,ethyl ester;Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[(‘2-1H-tetrazol-5-ylbiphenyl-4-yl);4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester
• CAS NO: 189400-21-3
• Molecular Formula: C45H44N6O3
• Molecular Weight: 716.87
• Mol File: 189400-21-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 889.7oC at 760 mmHg
• Flash Point: 491.9oC
• Appearance: /
• Density: 1.18g/cm3
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester(189400-21-3)
• EPA Substance Registry System: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester(189400-21-3)

Safety Data

• Hazardous Substances Data: 189400-21-3(Hazardous Substances Data)

Usage

Description

4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester, with the CAS number 189400-21-3, is a complex organic compound characterized by its unique molecular structure. It is an ethyl ester derivative of 1H-imidazole-5-carboxylic acid, featuring a hydroxy-methylethyl group, a propyl chain, and a tetrazol-5-yl-biphenyl moiety attached to the imidazole ring. 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester is known for its pharmaceutical properties, particularly as an angiotensin II receptor antagonist.

Uses

1. Used in Pharmaceutical Industry:
4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester is used as an angiotensin II receptor antagonist for the treatment of hypertension and heart failure. As an antagonist, it blocks the action of angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure and improving cardiovascular function.
2. Used in Research and Development:
4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester is also utilized in the research and development of new drugs targeting the renin-angiotensin system. Its unique structure and properties make it a valuable tool for understanding the mechanisms of action and potential therapeutic applications in various cardiovascular and renal diseases.
3. Used in Drug Synthesis:
In the field of medicinal chemistry, 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-[(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid ethyl ester serves as a key intermediate in the synthesis of novel angiotensin II receptor antagonists with improved pharmacological profiles, such as better bioavailability, longer duration of action, and fewer side effects.