18906-37-1

Basic information

• Product Name: 2,4-dimethoxybenzene-1-thiol
• Synonyms: 2,4-dimethoxybenzene-1-thiol;2,4-dimethoxybenzenethiol
• CAS NO: 18906-37-1
• Molecular Formula: C₈H₁₀O₂S
• Molecular Weight: 170.231
• Mol File: 18906-37-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 278.1 °C at 760 mmHg
• Flash Point: 122 °C
• Appearance: /
• Density: 1.134 g/cm³
• Vapor Pressure: 0.00734mmHg at 25°C
• Refractive Index: 1.549
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-dimethoxybenzene-1-thiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethoxybenzene-1-thiol(18906-37-1)
• EPA Substance Registry System: 2,4-dimethoxybenzene-1-thiol(18906-37-1)

Safety Data

• Hazardous Substances Data: 18906-37-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dimethoxybenzene-1-thiol is used as a pharmaceutical intermediate for the synthesis of various drugs and medications. Its unique chemical structure allows it to serve as a building block in the development of new pharmaceutical compounds, contributing to the advancement of medical treatments.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,4-dimethoxybenzene-1-thiol is utilized as a versatile intermediate for the production of a wide range of organic compounds. Its reactivity and functional groups make it a valuable component in the synthesis of various chemicals, including dyes, agrochemicals, and other specialty chemicals.
Used in Research and Development:
2,4-Dimethoxybenzene-1-thiol is also employed in research and development settings, where it is used to study the properties and behavior of thiol-containing compounds. Its unique structure allows scientists to explore new reaction pathways and develop innovative synthetic methods, further expanding the potential applications of this compound.

Physical state

2,4-dimethoxybenzene-1-thiol is a Low-Melting Solid.

InChI:InChI=1/C8H10O2S/c1-9-6-3-4-8(11)7(5-6)10-2/h3-5,11H,1-2H3

Upstream product

• 151-10-0 1,3-Dimethoxybenzene 
• 571167-30-1 3-(2,4-dimethoxyphenyl)-sulfanyl-propionic acid methyl ester 
• 160855-21-0 N-(2,4-dimethoxyphenylthio)phthalimide 
• 63624-28-2 2,4-dimethoxybenzenesulfonylchloride 
• 2735-04-8 2,4-Dimethoxyaniline 

Downstream Products

• 55990-92-6 1,2-bis(2,4-dimethoxyphenyl)disulfane 
• 1388758-92-6 1-(2,4-dimethoxyphenylthio)-3-(1H-indol-1-yl)propan-2-ol 
• 63624-33-9 1-(2,4-Dimethoxy-5-methylthiophenyl)-2-nitropropen 
• 79440-52-1 5-Methylthio-2,4-dimethoxyamphetamine 
• 63624-31-7 2,4-dimethoxy-5-(methylthio)benzaldehyde 
• 127905-84-4 [2-(2,4-Dimethoxy-phenylsulfanyl)-benzyl]-methyl-amine 
• 127905-75-3 N,N-dimethyl-2-(2,4-dimethoxyphenylthio)benzylamine 
• 127905-95-7 2-(2,4-Dimethoxy-phenylsulfanyl)-benzylamine 
• 127906-20-1 AE-641/30109032 
• 127906-35-8 4-(2-Methylaminomethyl-phenylsulfanyl)-benzene-1,3-diol 
• 127905-57-1 2-(2,4-Dimethoxy-phenylsulfanyl)-N,N-dimethyl-benzamide 
• 127905-52-6 2-(2,4-Dimethoxy-phenylsulfanyl)-N-methyl-benzamide 
• 127905-42-4 2-(2,4-Dimethoxy-phenylsulfanyl)-benzoyl chloride 
• 127905-46-8 2-(2,4-Dimethoxy-phenylsulfanyl)-benzamide 

Relevant articles and documents

Facile introduction of SH group on aromatic substrates via electrophilic substitution reactions

Herein, we describe a mild and efficient two-step procedure to introduce a thiol group on aromatic substrates. First, reaction with an activated sulfoxide leads to an arylsulfonium salt intermediate. Then, two successive β-elimination-based dealkylation reactions afford the desired arylthiols in good to excellent yields.

Phthalimidesulfenyl chloride. x1. a synthetic equivalent of hs+ and+s-s+ species in electrophilic aromatic substitutions

The reaction of phthalimidesulfenyl chloride, 1, with activated arenes provides monosubstituted phthalimidesulfenyl derivatives 3 which can be easily transformed into the corresponding disulfides 7, thiols 8 and masked thiols 9.

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5- trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric com