187237-37-2

Basic information

• Product Name: TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE
• Synonyms: 2-Amino-5-(aminomethyl)pyridine, 2-BOC protected;Carbamic acid,N-[5-(aminomethyl)-2-pyridinyl]-, 1,1-dimethylethyl ester;tert-butyl N-[5-(aMinoMethyl)pyridin-2-yl]carbaMate;5-AMinoMethyl-2-(Boc-aMino)pyridine, 97%;tert-Butyl [5-(aminomethyl)pyridin-2-yl]carbamate, 5-(Aminomethyl)-2-[(tert-butoxycarbonyl)amino]pyridine;tert-Butyl (5-(aminomethyl)
• CAS NO: 187237-37-2
• Molecular Formula: C₁₁H₁₇N₃O₂
• Molecular Weight: 223.274
• EINECS: -0
• Product Categories: pyridine
• Mol File: 187237-37-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 132-134℃
• Boiling Point: 321.371 °C at 760 mmHg
• Flash Point: 148.16 °C
• Appearance: /
• Density: 1.164 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 12.38±0.70(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE(187237-37-2)
• EPA Substance Registry System: TERT-BUTYL [(5-(AMINOMETHYL)PYRIDIN-2-YL]CARBAMATE(187237-37-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 187237-37-2(Hazardous Substances Data)

Usage

General Description

Tert-butyl [(5-(aminomethyl)pyridin-2-yl]carbamate is a chemical compound with the molecular formula C13H20N4O2. It is a white solid that is insoluble in water and is used as a reagent in chemical reactions and synthesis. The compound has a tert-butyl group and a pyridin-2-yl carbamate group, which makes it a valuable building block for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is commonly used as a protective group for amines in organic synthesis and serves as a precursor for the preparation of various compounds with biological activity. Tert-butyl [(5-(aminomethyl)pyridin-2-yl]carbamate is an important intermediate in the production of a wide range of chemical products and has numerous applications in the field of organic chemistry.

InChI:InChI=1/C11H17N3O2/c1-11(2,3)16-10(15)14-9-5-4-8(6-12)7-13-9/h4-5,7H,6,12H2,1-3H3,(H,13,14,15)

Upstream product

• 874-42-0 2,4-dichlorobenzaldeyhde 
• 4214-73-7 6-aminonicotinonitrile 
• 24424-99-5 di-tert-butyl dicarbonate 
• 902837-44-9 tert-butyl (5-cyanopyridin-2-yl)carbamate 

Downstream Products

• 1038387-99-3 C₁₈H₂₁N₃O₃ 
• 1363155-26-3 tert-butyl 5-((3-(4-(phenylsulfonyl)phenyl)ureido)methyl)pyridin-2-ylcarbamate 
• 1363150-15-5 tert-butyl N-{5-[({[4-(piperidine-1-sulfonyl)phenyl]carbamoyl}amino)methyl]pyridin-2-yl}carbamate 
• 1363152-08-2 1-(6-aminopyridin-3-ylmethyl)-3-(4-(piperidine-1-yl)sulfonyl)urea 
• 156973-09-0 2-amino-5-aminomethyl-pyridine 
• 1161013-91-7 [5-(3-{4-[6-Ethylamino-5-(2-(piperidin-1-yl)ethylcarbamoyl)pyridin-2-yl]phenyl}-ureidomethyl)pyridin-2-yl]carbamic acid tert-butyl ester 

Relevant articles and documents

SUBSTITUTED BENZAMIDES AS MODULATORS OF TREX1

Provided are compounds of Formula (I): (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with TREX1.

THERAPEUTIC INHIBITORY COMPOUNDS

The invention provides compounds of Formula I and Formula II: A-B-C-D-E-F-G-J (I) C-D-E-F-G-J (II) wherein A, B, C, D, E, F, G, and J have any of the values defined in the specification, and salts thereof. The compounds are useful for inhibiting plasma kallikrein, and for treating a disease or condition in an animal where inhibition of plasma kallikrein is indicated.