18704-37-5

Basic information

• Product Name: 8-Quinolinesulfonyl chloride
• Synonyms: Quinoline-8-sulfonylchloride,97%;8-Quinolinesulfonyl chloride >=96.0% (AT);8-Quinolinesulfonyl chloride 98%;8-Quinolinesulfonyl chloride≥ 98%(Titration);8-QUINOLINESULPHONYL CHLORIDE;AKOS B019400;ART-CHEM-BB B019400;QUINOLINE-8-SULPHONYL CHLORIDE
• CAS NO: 18704-37-5
• Molecular Formula: C₉H₆ClNO₂S
• Molecular Weight: 227.67
• EINECS: 242-515-5
• Product Categories: Chemical Synthesis;Heterocyclic Building Blocks;Quinoline&Isoquinoline;Heterocyclic Compounds;Condensation & Active Esterification;Quinolinecarboxylic Acids, etc.;Quinolines;Synthetic Organic Chemistry;Building Blocks;Heterocyclic Building Blocks;Building Blocks;C8 to C10
• Mol File: 18704-37-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 126-129 °C(lit.)
• Boiling Point: 306°C
• Flash Point: 306°C
• Appearance: white to light yellow crystal powder
• Density: 1.483 g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: 2-8°C
• Solubility: methanol: soluble10mg/mL, clear, colorless to light yellow
• PKA: 0?+-.0.17(Predicted)
• Sensitive: Moisture Sensitive
• BRN: 156347
• CAS DataBase Reference: 8-Quinolinesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Quinolinesulfonyl chloride(18704-37-5)
• EPA Substance Registry System: 8-Quinolinesulfonyl chloride(18704-37-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• RTECS: VC2830000
• F: 3-10-21
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 18704-37-5(Hazardous Substances Data)

Usage

Description

8-Quinolinesulfonyl chloride is a white to light yellow crystal powder that is a reactive chemical compound. It is known for its ability to react with aromatic or heterocyclic sulfonamides containing a free amino, imino, hydrazino, or hydroxyl group to form water-soluble compounds.

Uses

Used in Pharmaceutical Industry:
8-Quinolinesulfonyl chloride is used as a coupling reagent in oligonucleotide synthesis for the development of pharmaceutical compounds. Its reactivity allows for the formation of stable linkages between nucleotide units, which is crucial for the synthesis of therapeutic oligonucleotides.
Used in Organic Chemistry:
8-Quinolinesulfonyl chloride is used as a reagent in the synthesis of olefins from secondary esters at moderate temperatures. This application is valuable in organic chemistry for the production of olefins, which are important building blocks for a wide range of chemical compounds and materials.
These uses highlight the versatility of 8-Quinolinesulfonyl chloride as a chemical intermediate in both pharmaceutical and organic chemistry applications. Its reactivity and ability to form water-soluble compounds make it a valuable tool in the synthesis of various compounds.

InChI:InChI=1/C7H11BrN2/c1-7(2,3)6-5(8)4-9-10-6/h4H,1-3H3,(H,9,10)

Upstream product

• 85-48-3 8-quinolinesulfonic acid 
• 491-33-8 8-mercaptoquinoline 
• 16567-18-3 8-bromoquinoline 
• 1160-28-7 bis(8-quinolinyl)disulfide 
• 35203-91-9 8-quinolinesulfonamide 
• 91-22-5 quinoline 
• 142597-99-7 1-(quinoline-8-sulphonyl)-3-n-butylurea 

Downstream Products

• 35203-91-9 8-quinolinesulfonamide 
• 55180-87-5 8-quinolinesulfonyl azide 
• 1160-28-7 bis(8-quinolinyl)disulfide 
• 117800-91-6 trans-4-tert-butylcyclohexyl 8-quinolinesulfonate 
• 108293-28-3 (-)-<(-)-menthyl 8-quinolinesulfinate> 
• 117800-93-8 l-menthyl 8-quinolinesulfonate 
• 104502-94-5 N_α-(8-Chinolinsulfonyl)-4-cyanphenylalanin 
• 77244-88-3 8-quinolenesulfonyl-3-nitro-1,2,4-triazole 
• 83906-30-3 5'-O-quinolinesulfonyl-2',3'-O-dibenzoyluridine 
• 62862-08-2 cyclohexylmethyl 8-quinolinesulfonate 
• 117800-87-0 cyclohexyl 8-quinolinesulfonate 
• 2801-16-3 sodium quinoline-8-thiolate 
• 209349-60-0 1'-(3-((S)-(3,4-Dichlorophenyl))-4-(N-(quinoline-8-sulfonyl) (methylamino))-butyl)-spiro(2.3-dihydrobenzothiophene-3,4'-piperidine) 
• 351527-12-3 (S)-2-[(2-Nitro-benzyl)-(quinoline-8-sulfonyl)-amino]-propionic acid 

Relevant articles and documents

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Synthesis, Characterization, and Theoretical Studies of cis -Dichloridobis(8-quinolinethiolato)tin(iv) and bis(8-Sulfanylquinolinium) Hexachloridostannate(iv) Derivatives

The structural characterisation of bis(8-sulfanylquinolinium) hexachloridostannate(iv) (2) is reported and the variable reaction behaviour of this compound in different solvents has been explored. In particular, attempted recrystallization of 2 from chloroform and dichloromethane affords two polymorphs of cis-dichloridobis(8-quinolinethiolato)tin(iv), 3m and 3t, respectively. Attempted recrystallization of 2 from methanol gives crystals of 8,8′-dithiodiquinolinium hexachloridostannate(iv) 4. When 2 is dissolved in dimethyl sulfoxide in the presence of air, it undergoes oxidation to afford diquinolinyl-8,8′-disulfide 5. The molecular structures of the isolated compounds 2-4 are unambiguously authenticated by single crystal X-ray diffraction studies. The electronic structure properties of all the isolated compounds 2-4 are thoroughly studied by DFT calculations.

SULFONAMIDE OR AMIDE COMPOUNDS, COMPOSITIONS AND METHODS FOR THE PROPHYLAXIS AND/OR TREATMENT OF AUTOIMMUNE, INFLAMMATION OR INFECTION RELATED DISORDERS

The present invention related to novel sulfonamides or amides as TLR-4 antagonists, and pharmaceutical formulations containing the same and the methods of use thereof. Uses of the present novel sulfonamides or amides include, but are not limited to, the prophylaxis and/or treatment of autoimmune, inflammation, or infection related disorders.