18672-09-8

Basic information

• Product Name: Propanoic acid, 2-(4-chlorophenoxy)-, ethyl ester, (R)-
• CAS NO: 18672-09-8
• Molecular Formula: C11H13ClO3
• Molecular Weight: 228.675
• Mol File: 18672-09-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2-(4-chlorophenoxy)-, ethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2-(4-chlorophenoxy)-, ethyl ester, (R)-(18672-09-8)
• EPA Substance Registry System: Propanoic acid, 2-(4-chlorophenoxy)-, ethyl ester, (R)-(18672-09-8)

Safety Data

• Hazardous Substances Data: 18672-09-8(Hazardous Substances Data)

Upstream product

• 64-17-5 ethanol 
• 3307-39-9 (R)-2-(4-chlorophenoxy)propanoic acid 
• 6111-99-5 ethyl diazoalaninate 
• 106-48-9 4-chloro-phenol 
• 1193-00-6 sodium 4-chlorophenolate 
• 687-47-8 (S)-Ethyl lactate 
• 57057-80-4 ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate 

Downstream Products

• 3307-39-9 (R)-2-(4-chlorophenoxy)propanoic acid 

Relevant articles and documents

Planar chiral [2.2]paracyclophane-based bisoxazoline ligands: Design, synthesis, and use in cu-catalyzed inter- and intramolecular asymmetric O-H insertion reactions

Centrally chiral bisoxazolines connected directly to a planar chiral [2.2]paracyclophane backbone were synthesized and evaluated as asymmetric ligands in Cu-catalyzed intermolecular ethanolic O-H insertion reactions of α-diazo esters. The reactivities and enantioselectivities of Cu complexes of the synthesized bisoxazoline ligands were lower than those of ligands without central chirality. However, planar chiral [2.2] paracyclophane-based bisoxazoline ligands with an inserted benzene spacer that had a sterically demanding isopropyl substituent showed good enantioselectivities in inter- and intramolecular aromatic O-H insertion reactions, without the aid of central chirality.

Synthesis of 2-aryloxypropanoic acids analogues of clofibric acid and assignment of the absolute configuration by 1H NMR spectroscopy and DFT calculations

A new set of optically active 2-aryloxypropanoic acids has been synthesized through a simple strategy, in good yields and excellent enantiomeric excesses. Their absolute configuration was assigned by means of a NMR-based approach consisting of the derivatization of the carboxylic acids with ethyl mandelate and the comparison of the chemical shifts of the obtained diastereomers. The effectiveness of such an approach has been tested against a larger set of chiral α-substituted-carboxylic acids and by performing high level density functional theory (DFT) calculations on a set of low energy conformations for each diastereomeric derivative. The employed computational procedure has enabled us to find a semiquantitative relationship between the experimental NMR data and the theoretically calculated energy gaps which confirms the theoretical foundations of the NMR strategy and allows to understand when and why it is most likely to fail.

PROCESS FOR PREPARING (R)-ARYLOXYPROPIONIC ACID ESTER DERIVATIVES

The present invention relates to a method for preparing optically active (R)-aryloxypropionic acid ester derivatives, and more particularly to a method for preparing (R)- aryloxypropionic acid ester derivatives with high optical purity and good yield at low cost from phenol derivatives with various substituted functional groups and (S)-alkyl O-arylsulfonyl lactates.