185996-35-4Relevant articles and documents
Total synthesis of 5-epi-Torrubiellutin C and its biological evaluation
Mahipal, Bodugam,Singh, Ashita,Ummanni, Ramesh,Chandrasekhar, Srivari
, p. 15917 - 15927 (2013)
The total synthesis of 5-epi-Torrubiellutin C is described in a fully stereocontrolled manner and linear sequence involving high yielding steps. The synthetic strategy involves the dicyclohexylboron chloride mediated Paterson's aldol protocol, Horner-Emmo
Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics
Chang, Wonsuk,Mosley, Ralph T.,Bansal, Shalini,Keilman, Meg,Lam, Angela M.,Furman, Phillip A.,Otto, Michael J.,Sofia, Michael J.
, p. 2938 - 2942 (2012/06/15)
The HCV non-structural protein NS5A has been established as a viable target for the development of direct acting antiviral therapy. From computational modeling studies strong intra-molecular hydrogen bonds were found to be a common structural moiety withi
PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES
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Page/Page column 148, (2009/03/07)
The present invention relates to py razinone derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6 and R7 are as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.