18510-29-7Relevant articles and documents
Continuous-flow Si-H functionalizations of hydrosilanesviasequential organolithium reactions catalyzed by potassiumtert-butoxide
Lee, Hyune-Jea,Kwak, Changmo,Kim, Dong-Pyo,Kim, Heejin
supporting information, p. 1193 - 1199 (2021/02/26)
We herein report an atom-economic flow approach to the selective and sequential mono-, di-, and tri-functionalizations of unactivated hydrosilanesviaserial organolithium reactions catalyzed by earth-abundant metal compounds. Based on the screening of various additives, we found that catalytic potassiumtert-butoxide (t-BuOK) facilitates the rapid reaction of organolithiums with hydrosilanes. Using a flow microreactor system, various organolithiums bearing functional groups were efficiently generatedin situunder mild conditions and consecutively reacted with hydrosilanes in the presence oft-BuOK within 1 min. We also successfully conducted the di-funtionalizations of dihydrosilane by sequential organolithium reactions, extending to a gram-scale-synthesis. Finally, the combinatorial functionalizations of trihydrosilane were achieved to give every conceivable combination of tetrasubstituted organosilane libraries based on a precise reaction control using an integrated one-flow system.
Reactivity of Hypervalent Species: Reactions of Anionic Penta-Coordinated Silicon Complexes towards Nucleophiles
Boudin, Alain,Cerveau, Genevieve,Chuit, Claude,Corriu, Robert J. P.
, p. 101 - 106 (2007/10/02)
The reactivity of anionic penta-coordinated silicon complexes 4-O)2>-Na+ 1 with nucleophilic reagents has been studied. 1 can be reduced to organosilanes RSiH3 by metallic hydrides.Reactions with an excess of Grignard or organolithium reagents (R'MgX or R'Li) gave tetraorganosilanes RSiR'3.When only two molar equivalents of Grignard reagents (R'MgX) or lithium reagents (R'Li) are added to complexs 1 functional silanes RR'2SiX can be prepared.
Reaktivitaet von anionischen, fuenffach koordinierten Si-Komplexen gegenueber Nucleophilen
Boudin, Alain,Cerveau, Genevieve,Chuit, Claude,Corriu, Robert J. P.,Reye, Catherine
, p. 472 - 473 (2007/10/02)
-