18494-52-5

Basic information

• Product Name: 1-Piperidino-1-pentanone
• Synonyms: 1-Piperidino-1-pentanone
• CAS NO: 18494-52-5
• Molecular Formula: C₁₀H₁₉NO
• Molecular Weight: 169.264
• Mol File: 18494-52-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 282.5°Cat760mmHg
• Flash Point: 118°C
• Appearance: /
• Density: 0.949g/cm³
• Vapor Pressure: 0.00335mmHg at 25°C
• Refractive Index: 1.469
• CAS DataBase Reference: 1-Piperidino-1-pentanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidino-1-pentanone(18494-52-5)
• EPA Substance Registry System: 1-Piperidino-1-pentanone(18494-52-5)

Safety Data

• Hazardous Substances Data: 18494-52-5(Hazardous Substances Data)

Usage

Classification

Synthetic drug and designer drug

Chemical Class

Cathinone

Structural Relations

MDPV (Methylenedioxypyrovalerone) and α-PVP (Alpha-Pyrrolidinovalerophenone)

Psychoactive Effects

Increased energy, euphoria, and heightened alertness

Availability

Often sold as a research chemical or substitute for other stimulants like MDMA (Ecstasy) or amphetamines

Legal Status

Controlled substance in many countries

Regulation Purpose

To prevent misuse and health risks associated with consumption

Use and Distribution

Regulated due to potential for abuse and harmful effects

InChI:InChI=1/C10H19NO/c1-2-3-7-10(12)11-8-5-4-6-9-11/h2-9H2,1H3

Upstream product

• 110-89-4 piperidine 
• 110-59-8 pentanonitrile 
• 110-62-3 pentanal 
• 71-41-0 pentan-1-ol 
• 638-29-9 n-valeryl chloride 
• 109-52-4 valeric acid 
• 4426-47-5 butylboronic acid 
• 201230-82-2 carbon monoxide 
• 2173-56-0 n-pentyl n-pentanoate 
• 135676-71-0 1,5-Dipentanoyl-[1,3,5]triazinane-2,4-dione 

Downstream Products

• 49845-25-2 1-(pent-1-en-1-yl)piperidine 
• 1374639-81-2 2-butyl-3-benzoylimidazo[1,2-a]pyridine 

Relevant articles and documents

IrIII-Catalyzed direct syntheses of amides and esters using nitriles as acid equivalents: A photochemical pathway

An unprecedented IrIII[df(CF3)ppy]2(dtbbpy)PF6-catalyzed simple photochemical process for direct addition of amines and alcohols to the relatively less reactive nitrile triple bond is described herein. Various amides and esters are synthesized as the reaction products, with nitriles being the acid equivalents. A mini-library of different types of amides and esters is made using this mild and efficient process, which uses only 1 mol% of photocatalyst under visible light irradiation (λ = 445 nm). The reaction strategy is also efficient for gram-scale synthesis.

Cross-Dehydrogenating Coupling of Aldehydes with Amines/R-OTBS Ethers by Visible-Light Photoredox Catalysis: Synthesis of Amides, Esters, and Ureas

A straightforward synthesis of amides, ureas, and esters is reported by visible-light cross-dehydrogenating coupling (CDC) of aldehydes (or amine carbaldehydes) and amines/R-OTBS ethers by photoredox catalysis. The reaction is found to be general and high yielding. A plausible mechanistic pathway has been proposed for these transformations and is supported by appropriate controlled experiments.

Selective α-Oxyamination and Hydroxylation of Aliphatic Amides

Compared to the α-functionalization of aldehydes, ketones, even esters, the direct α-modification of amides is still a challenge because of the low acidity of α-CH groups. The α-functionalization of N?H (primary and secondary) amides, containing both an unactived α-C?H bond and a competitively active N?H bond, remains elusive. Shown herein is the general and efficient oxidative α-oxyamination and hydroxylation of aliphatic amides including secondary N?H amides. This transition-metal-free chemistry with high chemoselectivity provides an efficient approach to α-hydroxy amides. This oxidative protocol significantly enables the selective functionalization of inert α-C?H bonds with the complete preservation of active N?H bond.