180587-74-0 Usage
Description
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is a chiral purine derivative with the molecular formula C10H12ClN5O. It exists as a pair of enantiomers due to its chiral center and is commonly used as a research tool in the study of purinergic signaling and as a building block in the synthesis of nucleoside analogs. (R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol has also been investigated for its potential pharmacological properties, including its effects on adenosine receptors and its potential as an anti-cancer agent. It is a white to off-white solid and is typically handled and stored under controlled conditions due to its potential reactivity and toxicity.
Uses
Used in Pharmaceutical Research:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is used as a research tool for studying purinergic signaling, which plays a crucial role in various physiological and pathological processes. Understanding the effects of this compound on purinergic signaling can help in the development of new therapeutic agents targeting these pathways.
Used in Synthesis of Nucleoside Analogs:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is used as a building block in the synthesis of nucleoside analogs, which are important in the development of antiviral and anticancer drugs. Its unique structure allows for the creation of novel nucleoside analogs with potential therapeutic applications.
Used in Cancer Research:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol is being investigated for its potential as an anti-cancer agent. Its effects on adenosine receptors and other molecular targets may provide insights into the development of new cancer therapies.
Used in Drug Development:
(R)-1-(6-chloro-9H-purin-9-yl)propan-2-ol's potential pharmacological properties make it a valuable candidate for drug development. Its interactions with adenosine receptors and other molecular targets can be further explored to develop new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 180587-74-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,5,8 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 180587-74:
(8*1)+(7*8)+(6*0)+(5*5)+(4*8)+(3*7)+(2*7)+(1*4)=160
160 % 10 = 0
So 180587-74-0 is a valid CAS Registry Number.
180587-74-0Relevant articles and documents
Preparation method for tenofovir
-
Paragraph 0065-0071; 0072-0079, (2018/07/30)
The invention relates to the field of chemical synthesis, and in particular relates to a preparation method for tenofovir. The compound provided by the invention has a structure shown by a formula XIIin the description. The method for preparing the tenofovir based on a compound provided by the invention has the advantages that raw materials are cheap and easy to obtain, the process route is short, the conditions are mild and reliable, and the method is easily used for industrialized production.
The synthesis of tenofovir and its analogues via asymmetric transfer hydrogenation
Zhang, Qian,Ma, Bai-Wei,Wang, Qian-Qian,Wang, Xing-Xing,Hu, Xia,Xie, Ming-Sheng,Qu, Gui-Rong,Guo, Hai-Ming
supporting information, p. 2014 - 2017 (2014/05/06)
A series of tenofovir analogues with potential antiviral and immunobiologically active compounds were synthesized through an asymmetric transfer hydrogenation reaction from achiral purine derivatives. Up to 97% ee and good to excellent yields were achieved under mild conditions through short reaction steps. The present report suggests an efficient process to acquire tenofovir and its analogues.
