18015-04-8

Basic information

• Product Name: 5-(thiophen-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione
• Synonyms: 2,4,6(1H,3H,5H)-pyrimidinetrione, 5-(2-thienylmethylene)-; 5-(2-Thienylmethylene)pyrimidine-2,4,6(1H,3H,5H)-trione; 5-(2-thienylmethylidene)hexahydropyrimidine-2,4,6-trione
• CAS NO: 18015-04-8
• Molecular Formula: C₉H₆N₂O₃S
• Molecular Weight: 222.2205
• Mol File: 18015-04-8.mol
• Article Data: 10

Chemical Properties

• Density: 1.529g/cm³
• Refractive Index: 1.674
• CAS DataBase Reference: 5-(thiophen-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(thiophen-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione(18015-04-8)
• EPA Substance Registry System: 5-(thiophen-2-ylmethylidene)pyrimidine-2,4,6(1H,3H,5H)-trione(18015-04-8)

Safety Data

• Hazardous Substances Data: 18015-04-8(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 873-83-6 4-Amino-2,6-dihydroxypyrimidine 
• 1753-47-5 5-(4-dimethylaminobenzylidene)barbituric acid 
• 131196-45-7 N-[(1E)-thiophen-2-ylmethylidene]benzenemethanamine 
• 28162-32-5 2-(2-thienyl)-1-cyanoacrylonitrile 
• 67-52-7 BARBITURIC ACID 

Downstream Products

• 1001318-07-5 3-(2-thienyl)-2-phenyl-3,3a-dihydro-2H-pyrazolo[3,4-d]pyrimidine-4,6-(5H,7H)-dione 
• 98-03-3 thiophene-2-carbaldehyde 
• 1753-47-5 5-(4-dimethylaminobenzylidene)barbituric acid 
• 131196-45-7 N-[(1E)-thiophen-2-ylmethylidene]benzenemethanamine 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 3878-18-0 2-(2-thienyl)-1H-benzimidazole 

Relevant articles and documents

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Barbituric acid in the synthesis of fused 1,7-phenanthroline derivatives

New 7-aryl(hetaryl)-7,8,9,10,11,12-hexahydropyrimido[5,4-b][1,7] phenanthroline-9,11-diones have been synthesized by three-component condensation of barbituric acid with quinolin-5-amine and aromatic or heteroaromatic aldehydes.

Organocatalysis of c?￡/c?￡N and C?￡C/ C?￡N exchange in dynamic covalent chemistry

The reversibly formed C?￡N bond plays a very important role in dynamic covalent chemistry and the C?￡N/C?￡N exchange of components between different imine constituents to create dynamic covalent libraries has been extensively used. To facilitate diversity generation, we have investigated an organocatalyzed approach, using L-proline as catalyst, to accelerate the formation of dynamic libraries of [n×n] imine components. The organocatalysis methodology has also been extended, under somewhat modified conditions, to reversible C?￡C/C?￡N exchange processes between Knoevenagel derivatives of barbituric acid and imines, allowing for the generation of increased diversity. Copyright