179232-29-2

Basic information

• Product Name: Methyl 4-bromo-2-fluorobenzoate
• Synonyms: Methyl 4-bromo-2-fluorobenzoate;4-BROMO-2-FLUOROBENZOIC ACID METHYL ESTER;Fluoro-4-bromobenzoate
• CAS NO: 179232-29-2
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.04
• Product Categories: blocks;Bromides;Carboxes;FluoroCompounds;Aromatic Esters
• Mol File: 179232-29-2.mol
• Article Data: 29

Chemical Properties

• Melting Point: 58-60℃
• Boiling Point: 272.7±25.0℃ (760 Torr)
• Flash Point: 118.7±23.2℃
• Appearance: /
• Density: 1.577±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.006mmHg at 25°C
• Refractive Index: 1.531
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Methyl 4-bromo-2-fluorobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-bromo-2-fluorobenzoate(179232-29-2)
• EPA Substance Registry System: Methyl 4-bromo-2-fluorobenzoate(179232-29-2)

Safety Data

• Hazardous Substances Data: 179232-29-2(Hazardous Substances Data)

Usage

Description

Methyl 4-bromo-2-fluorobenzoate is the methyl ester derivative of 4-bromo-2-fluorobenzoic acid (B684620), characterized by its off-white powder form. It is a chemical compound with a unique structure that makes it a valuable reagent in the synthesis of specific pharmaceutical agents.

Uses

Used in Pharmaceutical Industry:
Methyl 4-bromo-2-fluorobenzoate is used as a reagent for the synthesis of aminopyridyl-based inhibitors. These inhibitors are specifically designed to target Trypanosoma cruzi CYP51, an enzyme crucial for the survival of the parasite responsible for Chagas disease. By inhibiting this enzyme, the compound contributes to the development of anti-Chagas agents, which are essential in combating this life-threatening disease.

InChI:InChI=1/C8H6BrFO2/c1-12-8(11)6-3-2-5(9)4-7(6)10/h2-4H,1H3

Upstream product

• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 151982-51-3 4-bromo-2-fluorobenzoyl chloride 
• 74-88-4 methyl iodide 

Downstream Products

• 777074-54-1 4-benzyl 1-methyl 2-fluorobenzene-1,4-dioate 
• 749928-52-7 2-(4-bromo-2-fluorophenyl)propan-2-ol 
• 908247-89-2 Methyl 4-(cyclopentylethynyl)-2-fluorobenzoate 
• 908247-50-7 (E)-2-fluoro-4-(3,3,3-trifluoroprop-1-enyl)benzoic acid 
• 65685-51-0 6-bromo-1,2-benzoxazol-3-ol 

Relevant articles and documents

HISTONE ACETYLTRANSFERASE (HAT) INHIBITOR AND USE THEREOF

The present invention relates to a histone acetyltransferase (HAT) inhibitor. Provided are a compound represented by general formula I, a pharmaceutically acceptable salt, a stereoisomer, an enantiomer, a diastereomer, an atropisomer, a racemate, a polymorph, a solvate or an isotope-labeled compound (including deuterium substitution) thereof, a preparation method therefor, a pharmaceutical composition comprising the same, and use thereof in the treatment of various HAT-related diseases or conditions.

CANCER TREATMENTS TARGETING CANCER STEM CELLS

Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O'), and (I):

BTK INHIBITOR

Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).