17886-71-4Relevant articles and documents
Synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole and imidazo [2, 1-b] thiazolo [5, 4-d] isoxazole derivatives
Jaberi, Hamid Reza,Noorizadeh, Hadi
experimental part, p. 1518 - 1525 (2012/06/01)
In this work we describe the synthesis of some novel fused imidazo [2, 1-b] [1, 3] thiazole derivatives. The reaction of 1, 2-diaminoethane 1 with carbon disulphide in H2O/ETOH as solvent furnishes 4, 5-dihydro-1H-imidazol- 2-thiol 2 under reflux condition. the reaction of 4, 5-dihydro-1H-imidazol-2- thiol on treatment with ethylchloro acetate and aromatic aldehyde in presence of anhydrous sodium acetate and acetic acid as solvent to give (Z)-2- (arylidene)-5, 6-dihydroimidazo [2, 1-b] [1, 3] thiazol-3 (2H)-one 3a-j. Compounds 3a-j was condensed with hydroxylamine to give 3- (aryl)-2, 3, 6, 7-tetrahydroimidazo [2, 1-b] [1, 3] thiazolo [5, 4-d] isoxazole 4a-j. The structures of the new compounds were established by elemental analyses, IR, 1H NMR and 13C NMR data.
Novel bridgehead nitrogen heterocycles: Synthesis and antimicrobial activity of 2H-imidazopyrazolothiazoles
Mohan, Jag,Kiran
, p. 898 - 900 (2007/10/02)
Synthesis of 3-substituted 3,3a,6,7-tetrahydro-2H-imidazopyrazolothiazoles (IIIa) and their 2-phenyl derivatives (IIIb) have been achieved in a single step by treating 2-arylidene-5,6-dihydroimidazothiazolidin-3-ones (II) with hydrazine and phenylhydrazine, respectively.Compounds II in turn have been obtained by condensing 2-mercaptoimidazoline with ethyl chloroacetate and aldehydes in the presence of pyridine and piperidine.Compounds III constitute a novel and hitherto unknown heterocyclic system.The antibacterial and antifungal activities of IIIa and IIIb have also been determined.