177551-63-2Relevant articles and documents
Oxidative trifluoromethylthiolations of aryl boronic acids using a copper/O2-based protocol
Zhang, Cheng-Pan,Vicic, David A.
, p. 1756 - 1758 (2012)
All you need is air: A new protocol has been developed which can mediate the coupling of aryl and vinyl boronic acids at room temperature in high yields (see scheme, dtbpy=4,4'-di-tert-butyl-2,2'-bipyridine). The reactions take place using simple copper(II) salts under aerobic conditions and do not require the use of expensive silver oxidants.
Gold (I/III)-Catalyzed Trifluoromethylthiolation and Trifluoromethylselenolation of Organohalides
Mudshinge, Sagar R.,Yang, Yuhao,Xu, Bo,Hammond, Gerald B.,Lu, Zhichao
supporting information, (2022/02/10)
The first C?SCF3/SeCF3 cross-coupling reactions using gold redox catalysis [(MeDalphos)AuCl], AgSCF3 or Me4NSeCF3, and organohalides as substrates are reported. The new methodology enables a one-stop shop synthesis of aryl/alkenyl/alkynyl trifluoromethylthio- and selenoethers with a broad substrate scope (>60 examples with up to 97 % isolated yield). The method is scalable, and its robustness is evidenced by the late-stage functionalization of various bioactive molecules, which makes this reaction an attractive alternative in the synthesis of trifluoromethylthio- and selenoethers for pharmaceutical and agrochemical research and development.
Metal-Free Direct Trifluoromethylthiolation of Aromatic Compounds Using Triptycenyl Sulfide Catalyst
Kurose, Ryo,Nishii, Yuji,Miura, Masahiro
supporting information, p. 2380 - 2385 (2021/04/05)
Herein we report an efficient synthetic method for the electrophilic trifluoromethylthiolation of aromatic compounds. The key is to use triptycenyl sulfide (Trip-SMe) and TfOH to enhance the electrophilicity of SCF3 fragment through the formation of sulfonium intermediates. This method enables direct installation of an SCF3 group onto unactivated aromatics at room temperature, adopting a commercially available saccharin-based reagent. Preliminary DFT calculation was carried out to investigate the substitution effect on the catalytic activity.
Preparation method of trifluoromethyl aryl thioether
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Paragraph 0027; 0036-0038; 0042-0060, (2021/02/20)
The invention discloses a preparation method of trifluoromethyl aryl thioether, and belongs to the field of chemicals for daily use in chemical industry. Aryl sulfinate and trifluoromethyl trimethyl silane are used as substrates, no transition metal catalyst is needed, and trifluoromethyl aryl thioether is obtained through reaction under the action of an additive, an oxidizing agent and alkali. The reaction can be carried out in a room-temperature environment, the reaction is green, simple and convenient, the reaction yield is as high as 55%, and a new approach of a trifluoromethylthiolation indirect method is provided in the field of fluorine chemistry; the obtained product has wide application in the fields of medicines, pesticides and materials.