17680-99-8 Usage
Description
P-TOLYL-BETA-D-GLUCURONIDE is a glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen is replaced by a p-tolyl group. It is a metabolite of o-Cresol (C781910), a compound that has been utilized as a disinfectant and has also been employed as an antiseptic in surgical procedures.
Uses
Used in Disinfection and Antisepsis:
P-TOLYL-BETA-D-GLUCURONIDE is used as a metabolite in the disinfection and antisepsis industry for its association with o-Cresol, a compound known for its disinfectant and antiseptic properties. This makes it a valuable component in the development and enhancement of disinfectants and antiseptics for various applications, including medical and hygiene purposes.
Used in Pharmaceutical and Chemical Research:
As a metabolite of o-Cresol, P-TOLYL-BETA-D-GLUCURONIDE can be utilized in pharmaceutical and chemical research to study the effects and interactions of o-Cresol in various settings. This can lead to the development of new drugs, therapies, or chemical compounds with improved properties and applications.
Used in Environmental Applications:
Given its connection to o-Cresol, a compound with disinfectant properties, P-TOLYL-BETA-D-GLUCURONIDE may also find use in environmental applications, such as water treatment and purification processes. Its role in these applications could involve the breakdown or neutralization of harmful substances, contributing to a cleaner and safer environment.
Check Digit Verification of cas no
The CAS Registry Mumber 17680-99-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,6,8 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 17680-99:
(7*1)+(6*7)+(5*6)+(4*8)+(3*0)+(2*9)+(1*9)=138
138 % 10 = 8
So 17680-99-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H16O7/c1-6-2-4-7(5-3-6)19-13-10(16)8(14)9(15)11(20-13)12(17)18/h2-5,8-11,13-16H,1H3,(H,17,18)/t8-,9-,10+,11-,13+/m0/s1
17680-99-8Relevant articles and documents
Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge
Cho, Joo-Youn,Matsubara, Tsutomu,Kang, Dong Wook,Ahn, Sung-Hoon,Krausz, Kristopher W.,Idle, Jeffrey R.,Luecke, Hans,Gonzalez, Frank J.
experimental part, p. 1063 - 1074 (2010/09/16)
Farnesoid X receptor (FXR) is a nuclear receptor that regulates genes involved in synthesis, metabolism, and transport of bile acids and thus plays a major role in maintaining bile acid homeostasis. In this study, metabolomic responses were investigated in urine of wild-type and Fxr-null mice fed cholic acid, an FXR ligand, using ultra-performance liquid chromatography (UPLC) coupled with electrospray time-of-flight mass spectrometry (TOFMS). Multivariate data analysis between wild-type and Fxr-null mice on a cholic acid diet revealed that the most increased ions were metabolites of p-cresol (4-methylphenol), corticosterone, and cholic acid in Fxr-null mice. The structural identities of the above metabolites were confirmed by chemical synthesis and by comparing retention time (RT) and/or tandem mass fragmentation patterns of the urinary metabolites with the authentic standards. Tauro-3α,6,7α,12α-tetrol (3α,6,7α,12α- tetrahydroxy-5β-cholestan-26-oyltaurine), one of the most increased metabolites in Fxr-null mice on a CA diet, is a marker for efficient hydroxylation of toxic bile acids possibly through induction of Cyp3a11. A cholestatic model induced by lithocholic acid revealed that enhanced expression of Cyp3a11 is the major defense mechanism to detoxify cholestatic bile acids in Fxr-null mice. These results will be useful for identification of biomarkers for cholestasis and for determination of adaptive molecular mechanisms in cholestasis.
