17630-76-1Relevant articles and documents
5-Chloro- and 5,7-dichloroisatin by chlorination of isatin with trichloroisocyanuric acid
Ribeiro,Da Silva,De Almeida Violante,Rezende,Pinto
, p. 265 - 267 (2005)
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REVERSIBLE MONOAMINE OXIDASE INHIBITORS IN THE INDOLINONE SERIES
Tsedere, D. G.,Grinberg, B. A.,Roska, A. S.,Zorin, L. M.,Zhungietu, G. I.,Prikulis, A. A.
, p. 304 - 307 (1984)
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R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond
Bondarenko, Oksana B.,Karetnikov, Georgy L.,Komarov, Arseniy I.,Pavlov, Aleksandr I.,Nikolaeva, Svetlana N.
supporting information, p. 322 - 332 (2021/01/14)
A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.
Synthesis and evaluation of tryptanthrins as antitumor agents
Hou, Baolong,Li, Wenyu,Liu, Jianli,Wang, Cuiling,Zhou, Ying
supporting information, (2021/10/01)
Here, an efficient and convenient method has been developed for the rapid preparation of N-substituted tryptanthrin analogues through the reaction of tryptanthrins and secondary amines under mild reaction conditions. All compounds were tested for their anti-tumor activity in cancer cell lines by MTT assay. The results showed that some of them exhibited anti-tumor activity against human tumor cell lines A549, HCT116, MDA-MB-231 with IC50 mean values at a low micromolar level. In particular, compound 3b induced G2/S cell cycle arrest and apoptosis in A549 cells dose-dependently.
1-benzylisatin derivative as well as synthesis method and application thereof
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Paragraph 0082-0086, (2020/10/20)
The invention relates to a 1-benzylisatin derivative as well as a synthesis method and application thereof, belongs to the technical field of medicines, and relates to a general formula (I) in which R1, R2 and R3 are different substituents. The invention discloses structures of the compounds, a synthesis method of the compounds, inhibitory activity of acetylcholin esterase and inhibitory activityof histone deacetylase 6; and the compounds can be further developed into drugs for treating Alzheimer's disease.