1762-80-7Relevant articles and documents
Generation of Oxazolidine-2,4-diones Bearing Sulfur-Substituted Quaternary Carbon Atoms by Oxothiolation/Cyclization of Ynamides
Huang, Hai,Fan, Junzhen,He, Guangke,Yang, Zhimin,Jin, Xiaodong,Liu, Qi,Zhu, Hongjun
supporting information, p. 2532 - 2538 (2016/02/12)
A novel method for metal-free oxothiolation of ynamides to construct oxazolidine-2,4-diones bearing sulfur-substituted quaternary carbon atoms has been developed. It represents a rare C-O bond cleavage of ynamides, as well as a facile and tandem approach for the formation of C-O, C-S, and C-Cl bonds. This redox-neutral protocol can be applied to the synthesis of multisubstituted oxazolidine-2,4-diones with good chemoselectivity and good yields of isolated products under mild conditions.